Antiparasitic And Antimicrobial Constituents From Terminalia Brownii
Date
2013Author
Machumi, F
Zhang, J
Midiwo, JO
Jacob, MR
Khan, SI
Tekwani, BL
Walker, LA
Muhammad, I
Language
enMetadata
Show full item recordAbstract
Terminalia brownii is an African medicinal plant used to treat parasitic and microbial infections. A new oleanane-type triterenoid was isolated from its stem bark extract by bioassay-guided fractionation using the method of chromatographic separations and was identified as 3,24-O-ethylidenyl-2,19-dihydroxyolean-12-en-28-oic acid (1), along with seven known oleanane-type triterpenoids and seven ellagic acid derivatives. The compounds were evaluated for their antiplasmodial, antileishmanial and antimicrobial activities giving the most potent antiplasmodial activity with IC50 values of 2.76 µg/mL for 23-galloylarjunolic acid (2) against P. falciparum W2 strain and the most potent antimicrobial activity with IC50 values of 0.32 µg/mL for diellagic lactone (3) against C. glabrata.
URI
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0033-1348703http://hdl.handle.net/11295/73764
Citation
Machumi, F., Zhang, J., Midiwo, J. O., Jacob, M. R., Khan, S. I., Tekwani, B. L., ... & Muhammad, I. (2013). Antiparasitic and Antimicrobial Constituents from Terminalia brownii. Planta Medica, 79(10), PN22.Publisher
University of Nairobi