Journal Articles: Recent submissions
Now showing items 4821-4840 of 29992
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Current perspectives in drug discovery against tuberculosis from natural products
(Elsevier, 2015)Currently, one third of the world’s population is latently infected with Mycobacterium tuberculosis (MTB), while 8.9–9.9 million new and relapse cases of tuberculosis (TB) are reported yearly. The renewed research interests ... -
Variability and trends in past, current and future climate in East Africa
(University of Nairobi, 2015)This study evaluates the climate variability and change in past, current and future climate in East Africa (EA) using high resolution regional models under the CO-ordinated Regional climate Downscaling Experiment (CORDEX). ... -
Brine shrimp toxicity and in vitro antimicrobial activity of Piliostigma thonningii (Schum.) Milne-Redh. [Leguminosae-Caesalpinioideae] from Kenya and Malawi against some pathogens of human and veterinary importance
(2013)Many microorganisms are responsible for causing serious diseases of bacterial origin. Development of drug resistance in animal and human pathogens against commonly used antibiotics has necessitated a search for new ... -
Atmospheric divergence over equatorial East Africa and its influence on distribution of rainfall
(University of Nairobi, 2015)Spatial and temporal variability of divergence is analysed over equatorial East Africa. According to the analysis, seasonal march of upper level divergence is bimodal. There is peak upper level divergence during March-April-May ... -
The Involvement of Human Cyr61 in Heregulin Induction of Breast Tumor Progression
(2003)This fellowship, originally granted to Dr. M. Tsai and later transferred to Dr. H. Oketch-Rabah in the laboratory of Dr. R. Lupu, was initially concerned with the role of the cytokine heregulin, in the regulation of hormone ... -
Malaria N 9-Subject N 15
(2003) -
Mondia whitei, a medicinal plant from Africa with aphrodisiac and antidepressant properties: a review
(2012)This paper reviews the literature concerning the ethnobotany, phytochemistry, and pharmacology of Mondia whitei, which is also known as Mondia whytei, African ginger or simply as mondia. Mondia is used in many parts of ... -
A New Class of Spermidine-Derived Alkaloids
(2003)Four new alkaloids, dovyalicins A−D, were isolated from Dovyalis macrocalyx. Their structures were established by two-dimensional COSY, NOESY, HSQC, and HMBC NMR experiments as well as chiroptical methods. The compounds, ... -
Contributions of Atlantic ocean to June - August rainfall over Uganda and Western Kenya
(University of Nairobi, 2015)This study investigates the contributions of Atlantic Ocean to June-August rainfall over Uganda and western Kenya (KU). The study utilized the following datasets: precipitation from the Global Precipitation Climatology ... -
Dovyalicin-Type Spermidine Alkaloids from Dovyalis Species
(2006)Phytochemical investigations of Dovyalis abyssinica, D. hebecarpa, and D. macrocalyx revealed two new spermidine-type alkaloids, dovyalicin E (3) and dovyalicin F (4), along with the previously described dovyalicin A (1), ... -
Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth
(2003)Black cohosh is an increasingly popular alternative to estrogen replacement therapy for the relief of menopausal symptoms, primarily hot flushes. However, an important consideration for long-term therapy is potential ... -
Antimalarial Activity of Some Plants Traditionally used in Meru district of Kenya
(2007)Ten plant extracts commonly used by the Meru community of Kenya were evaluated for the in vitro antiplasmodial, in vivo antimalarial, cytotoxicity and animal toxicity activities. The water and methanol extracts of Ludwigia ... -
In vitro activity of selected medicinal plants in Kenya on Trypanosoma evansi.
(University of Nairobi, 2013)Trypanosomiasis, a protozoan disease causes morbidity and death to humans and severely limits livestock production in endemic areas. It occurs predominantly in Africa, South America and Asia. Although chemotherapy has been ... -
Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Cancer Latency and Affect Tumor Type
(2011)Tissue microenvironment is an important determinant of carcinogenesis. We demonstrate that ionizing radiation, a known carcinogen, affects cancer frequency and characteristics by acting on the microenvironment. Using a ... -
Proliferation of estrogen receptor-α-positive mammary epithelial cells is restrained by transforming growth factor-β1 in adult mice
(2005)Transforming growth factor (TGF)-β1 is a potent inhibitor of mammary epithelial proliferation. In human breast, estrogen receptor (ER)-α cells rarely co-localize with markers of proliferation, but their increased frequency ... -
Retinoblastoma in Kenya: survival and prognostic factors
(University of Nairobi, 2015-03)BACKGROUND: In industrialized nations a curative therapy of retinoblastoma can be achieved in a large number of patients due to timely diagnosis and therapy. In developing countries the survival rates are much lower and ... -
Leaf compounds in potential plantation species of Aloe in Kenya
(1997)Many Aloe species are valued for the healing properties associated with the leaf tissues, a factor that has led to over-exploitation of natural populations and endangerment of some local Kenyan species. While trade in ...
