Journal Articles: Recent submissions
Now showing items 8401-8420 of 29992
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Dislocation of the elbow with ipsilateral forearm fracture. Six particular cases.
(University of Nairobischool of public health, 2013-10)Elbow dislocation associated with ipsilateral radial shaft fracture is an infrequent injury (nine cases reported in the literature). We present six new cases observed between 2006 and 2012, with an average age of 31 years ... -
Health financing reform in Kenya - assessing the social health insurance proposal.
(WHOCollege of Health Sciences, University of Nairobi, 2007)Kenya has had a history of health financing policy changes since its independence in 1963. Recently, significant preparatory work was done on a new Social Health Insurance Law that, if accepted, would lead to universal ... -
Ultrasound guided lumbar puncture in emergency department: Time saving and less complications.
(University of Nairobischool of public health, 2013-04)BACKGROUND: Lumbar puncture (LP) is an essential procedure in the diagnosis and treatment of several critical situations. This procedure is routinely performed by palpating external landmarks to find the most appropriate ... -
Solitary plasmacytoma of the mandible - a rare entity
(University of NairobiCollege of Health Science, 2013)Plasma cell dyscrasias (multiple myeloma, solitary plasmocytoma of bone and extra medullary plasmocytoma) are cha¬racterized by a monoclonal neoplastic proliferation of plasma cells of which Solitary plasmocytoma of bone ... -
Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model.
(University of NairobiCollege of Health Science, 2013)Curcumin, the active principle present in the yellow spice turmeric, has been shown to exhibit various pharmacological actions such as antioxidant, anti-inflammatory, antimicrobial, and anti-carcinogenic activities. ... -
Engineered reversal of drug resistance in cancer cells--metastases suppressor factors as change agents.
(University of NairobiCollege of Health Science, 2013)Building molecular correlates of drug resistance in cancer and exploiting them for therapeutic intervention remains a pressing clinical need. To identify factors that impact drug resistance herein we built a model that ... -
Identification of trypanosomes in Glossina pallidipes and G. longipennis in Kenya.
(School of Biological Sciences, 2004-03)The polymerase chain reaction (PCR) was used to identify trypanosomes in Glossina pallidipes and G. longipennis caught in Kenya. Of 3826 flies dissected, 188 (4.9%) were parasitologically positive overall. The infection ... -
Comparison of two microdiffusion methods used to measure ionizable fluoride in cows' milk.
(University of NairobiDepartment of Chemistry, 1995-08)Two microdiffusion methods for measuring ionizable fluoride in cows' milk have been compared. The comparison includes diffusion time, amount of fluoride in spiked and unspiked milk samples and the effect of aluminium as ... -
Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930
(College of Biological and Physical Sciences ,Department of physics, 2011)The quinoline domain of OSI-930, a dual inhibitor of receptor tyrosine kinases (RTKs) c-Kit and KDR, was modified in an effort to further understand the SAR of OSI-930, and the binding site characteristics of c-Kit and ... -
Effect of interfering ions on hexamethyldisiloxane microdiffusion method
(University of NairobiDepartment of Chemistry, 1997-10)Acid diffusion in the presence of hexamethyldisiloxane (HMDS) enables complete recovery of ionic fluoride from standards containing varying concentrations of aluminium as one of the main interfering ions. Acid diffusion ... -
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
(College of Biological and Physical Sciences ,Department of physics, 2012)BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated ... -
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
(College of Biological and Physical Sciences ,Department of physics, 2012)Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ... -
OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance
(College of Biological and Physical Sciences ,Department of physics, 2012)OSI-930, a dual c-Kit and KDR tyrosine kinase inhibitor, is reported to have undergone a Phase I dose escalation study in patients with advanced solid tumors. A series of fifteen pyridyl and phenyl analogues of OSI-930 ... -
CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900
(College of Biological and Physical Sciences ,Department of physics, 2012)We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ... -
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
(College of Biological and Physical Sciences ,Department of physics, 2012)Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data ... -
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes
(College of Biological and Physical Sciences ,Department of physics, 2013)Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ... -
How do novel molecular genetic markers influence treatment decisions in acute myeloid leukemia?
(College of Biological and Physical Sciences ,Department of physics, 2012)Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults, and the majority of patients with AML die from relapsed disease. Although many studies over the past 4 decades have identified disease ... -
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
(College of Biological and Physical Sciences ,Department of physics, 2013)Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ... -
African programme: kenya.
(Department of Ophthalmology, University of Nairobi, 2000) -
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
(College of Biological and Physical Sciences ,Department of physics, 2013)Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...
