Journal Articles: Recent submissions
Now showing items 9741-9760 of 29992
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Investigation of monovalent and bivalent enantioselective molecular recognition by electrospray ionization-mass spectrometry and tandem mass spectrometry.
(University of NairobiFaculty of medicine, 2008)In this work is described the investigation of bivalent versus monovalent enantioselective molecular recognition in the context of enantioselective separations. Electrospray ionization-mass spectrometry (ESI-MS) and tandem ... -
Lipid nanoparticles for parenteral delivery of actives.
(University of NairobiFaculty of medicine, 2008)The present review compiles the applications of lipid nanoparticles mainly solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid drug conjugates (LDC) in parenteral delivery of pharmaceutical ... -
Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity.
(University of NairobiFaculty of medicine, 2008)Ficus racemosa belongs to the family of Moraceae and is commonly known as 'Gular' in north India. Bio-activity guided isolation work on the fruits of F. racemosa resulted in the identification of antidiabetic active ... -
Policy considerations and the rule of law in East Africa.
(University of NairobiInstitute of Develpment Studies, 1975) -
Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells.
(University of NairobiFaculty of medicine, 2009)The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed by approximately 90% of human breast cancers. However, there are no effective agents that directly inhibit MUC1 and induce death of breast cancer cells. We have ... -
MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor.
(University of NairobiFaculty of medicine, 2009)Nuclear factor-kappaB (NF-kappaB) is constitutively activated in diverse human malignancies. The mucin 1 (MUC1) oncoprotein is overexpressed in human carcinomas and, like NF-kappaB, blocks cell death and induces transformation. ... -
MUC1 oncoprotein is a druggable target in human prostate cancer cells.
(University of NairobiFaculty of medicine, 2009-11)Human prostate cancers are dependent on the androgen receptor for their progression. The MUC1 heterodimeric oncoprotein is aberrantly overexpressed in prostate cancers; however, it is not known if MUC1 is of functional ... -
Evaluation of smut inoculation techniques in sugarcane seedlings
(Kenya Sugar Research Foundation, Kisumu, KenyaDepartment of Plant Science and Crop Protection, 2008)Smut disease of sugarcane, caused by the fungus Ustilago scitaminea Sydow, can cause considerable yield losses and reductions in cane quality. To investigate the reactions of the seedlings to smut, three different inoculation ... -
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.
(University of NairobiFaculty of medicine, 2009)Signal transducer and activator of transcription 1 (STAT1) is activated in the inflammatory response to interferons. The MUC1 oncoprotein is overexpressed in human breast cancers. Analysis of genes differentially expressed ... -
Discolouration of Restorative Materials by beverages
(School of Dental Sciences, 1999) -
Biocompatible microemulsions for fabrication of glyceryl monostearate solid lipid nanoparticles (SLN) of tretinoin.
(University of NairobiFaculty of medicine, 2009-08)The objective of the present investigation was to fabricate glyceryl monostearate SLN by employing a biocompatible microemulsion as a template. Biocompatible excipients such as Tween 20 (as a surfactant) and Transcutol P ... -
MUCIN 1 Oncoprotein Expression Is Suppressed By The Mir-125b Oncomir.
(University of NairobiFaculty of medicine, 2010)The MUC1 oncoprotein is overexpressed in most human breast cancers by mechanisms that are incompletely understood. The microRNA, miR-125b, is downregulated in breast cancer cells. The present studies demonstrate that the ... -
Androgen receptor regulates expression of the MUC1-C oncoprotein in human prostate cancer cells.
(University of NairobiFaculty of medicine, 2011)The MUC1 heterodimeric oncoprotein is aberrantly overexpressed in human prostate cancers with more aggressive pathologic and clinical features. However, the signals that regulate MUC1 expression in prostate cancer cells ... -
The Role of Multimodel Climate Forecasts in Improving Water and Energy Management over the Tana River Basin, Kenya
(University of Nairobi,Metereology Department, 2013)The Masinga Reservoir located in the upper Tana River Basin, Kenya, is extremely important in supplying country’s hydropower and protecting downstream ecology. The Dam serves as the primary storage reservoir, controlling ... -
State of the climate in 2010
(University of Nairobi,School of Law, 2010) -
Excavations at the site of Hyrax Hill, 1990.
(University of NairobiDepartment of History and Archaeological Studies, 1991) -
Hyrax Hill: 50 years of archaeological research.
(University of NairobiDepartment of History and Archaeological Studies, 1993) -
Archaeology of Pli - Pleistocene Hominids in Eastern Africa
(University of NairobiDepartment of History and Archaeological Studies, 2009) -
The Practicing Teacher of History and Historical Objectivity
(University of NairobiDepartment of History and Archaeological Studies, 2010)
