Prevalence of chronic rhinosinusitis in children with dyspepsia at Kenyatta national hospital and Gertrude children’s hospital

Abstract

Background: Chronic rhinosinusitis (CRS) is a complex condition with multitude of risk factors and has been found to affect both adult and paediatric population. Dyspepsia (GERD and H.Pylori) maybe one of the factors associated with chronic rhinosinusitis. Objectives: Study determined the prevalence of CRS in children diagnosed with dyspepsia. This was achieved by establishing the prevalence of H.pylori and GERD among children diagnosed with dyspepsia and the coexistence of CRS with dyspepsia. Study methodology: This is hospital based cross sectional descriptive study that was carried out at Kenyatta National Hospital and Gertrude’s Children's Hospital. 96 children diagnosed with dyspepsia were proportionately selected from the two hospitals using simple random sampling. Informed consent was obtained from the parent/guardian. CRS and dyspepsia were clinically diagnosed and Rome III criteria used for dyspepsia. H.pylori Antigen Stool Test done and findings recorded in a questionnaire. Data in filled questionnaires was entered, and analyzed using SPSS Vs. 20. Baseline characteristics were compared Spearman Rho’ Chi Square test was used to test associations. Logistic regression was used to analyze statistically significant data. Results: Ninety six dyspeptic paediatric patients were analyzed for H. pylori Antigen stool test, Reflux symptom index and CRS. CRS prevalence was 41.7%, H. pylori prevalence was 60.4% and GERD was 78.5%. CRS with GERD had p value = 0.00001 (OR-38.07), CRS with H. Pylori had p value = 0.0252(OR-2.95) and CRS with GERD and H. Pylori had p value = 0.001(OR-20.05). Conclusion: GERD is one of the CRS causative risk factor with a significant correlation and clinicians should have high index of suspicion