| dc.contributor.author | Yenesew, A | |
| dc.contributor.author | Gumula, I | |
| dc.contributor.author | Erdélyi, M | |
| dc.contributor.author | Patrick., A | |
| dc.contributor.author | Omolo, Isaiah Ndiege P S | |
| dc.contributor.author | Omolo, N | |
| dc.contributor.author | Sunnerhagen, P | |
| dc.date.accessioned | 2015-02-04T08:33:36Z | |
| dc.date.available | 2015-02-04T08:33:36Z | |
| dc.date.issued | 2014 | |
| dc.identifier.citation | Yenesew A, Gumula I, Erdélyi M, Patrick. A, J Isaiah Omolo Ndiege PS, Omolo, N, Sunnerhagen P. "Cytotoxic and Antioxidant Flemingins G-P from the Leaves of Flemingia grahamiana." Journal of Natural Products . 2014. | en_US |
| dc.identifier.uri | http://hdl.handle.net/11295/80149 | |
| dc.description.abstract | The known flemingins A-C (1-3) and nine new chalcones, named flemingins G-O (4-12), along with deoxyhomoflemingin (13) and emodin (14) were isolated from a leaf extract of Flemingia grahamiana. The isolated chalcones were found to have a geranyl substituent modified into a chromene ring possessing a residual chain, as shown by spectroscopic methods. The leaf extract showed an IC50 value of 5.9 μg/mL in a DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The chalcones flemingins A, B, C, G, and H were active in the DPPH radical scavenging assay (ED50 4.4-8.9 μM), while flemingins A and C showed cytotoxicity against MCF-7 human breast cancer cells (IC50 8.9 and 7.6 μM, respectively). | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | University of Nairobi | en_US |
| dc.title | Cytotoxic and antioxidant flemingins g-p from the leaves of flemingia grahamiana | en_US |
| dc.type | Article | en_US |
| dc.type.material | en | en_US |
