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Now showing items 10111-10120 of 10378
In Vitro Anti-hiv and Cytotoxic Effects of Pure Compounds Isolated From Croton Macrostachyus Hochst. Ex Delile
(University of Nairobi, 2022)
Croton macrostachyus is an important plant in traditional African medicine, widely utilized to treat a variety of diseases. In Kenya, HIV-infected patients use leaf and root decoctions of the plant as a cure for cough, ...
High Level of Pre-Treatment HIV-1 Drug Resistance and Its Association with HLA Class I-Mediated Restriction in the Pumwani Sex Worker Cohort
(University of Nairobi, 2022-01)
Background: We analyzed the prevalence of pre-antiretroviral therapy (ART) drug resistance mutations (DRMs) in a Kenyan population. We also examined whether host HLA class I genes influence the development of pre-ART ...
Psychological Experiences of Caregivers of Adolescents Diagnosed With Substance Use Disorder Attending a Youth Centre in a Low-resource Setting
(University of Nairobi, 2022)
Caregivers, whether a biological parent, adoptive parent, or a relative such as a grandparent, of adolescent with substance use disorder (SUD) undergo immense psychological and social strains, as they have to deal with ...
Global article collection: essential reads from around the world
(University of Nairobi, 2022-01)
Progress on the national action plan of Pakistan on antimicrobial resistance (AMR): a narrative review and the implications
(University of Nairobi, 2022-01)
Introduction: The emergence of antimicrobial resistance (AMR) is a threat to public health. In 2015, the World Health Organization (WHO) introduced a global action plan to tackle AMR in the World Health Assembly. Pakistan's ...
Prevalence of Trachomatous Trichiasis in Ten Evaluation Units of Embu and Kitui Counties, Kenya
(University of Nairobi, 2022-01)
Background: Late-stage blinding sequalae of trachoma such as trachomatous trichiasis (TT) typically take decades to develop and often do so in the absence of ongoing ocular Chlamydia trachomatis infection. This suggests ...
Effects of cytochrome P450 2B6 and constitutive androstane receptor genetic variation on Efavirenz plasma concentrations among HIV patients in Kenya
(University of Nairobi, 2022-03)
The effects of genetic variation of cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) on efavirenz (EFV) plasma concentration was evaluated among 312 HIV patients in Nairobi Kenya. The EFV plasma ...
Pairwise Joint Modeling of Clustered and High-dimensional Outcomes With Covariate Missingness in Pediatric Pneumonia Care
(University of Nairobi, 2022)
Multiple outcomes reflecting different aspects of routine care are a common phenomenon in health care research. A common approach of handling such outcomes is multiple univariate analyses, an approach which does not allow ...
Dynamic Changes in Breast Milk Microbiome in the Early Postpartum Period of Kenyan Women Living With Hiv Are Influenced by Antibiotics but Not Antiretrovirals
(University of Nairobi, 2022)
Shared bacteria between maternal breast milk and infant stool, infers that transfer of maternal breast milk microbiota through breastfeeding seeds the establishment of the infant gut microbiome. Whether combination ...
An Interesting Case of Fatal Myasthenic Crisis Probably Induced by the COVID-19 Vaccine
(University of Nairobi, 2022-03)
A myasthenic crisis is a severe, life-threatening exacerbation of myasthenia gravis that causes a rapid onset of muscle weakness and fatigue that may result in tetraparesis, dyspnea, respiratory insufficiency, aspiration, ...