Faculty of Health Sciences (FHS): Recent submissions
Now showing items 2781-2800 of 10418
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Short report: Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodeficiency virus 1. , ,, , , .
(University of NairobiCollege of Health Science, 2004)Abstract To investigate whether infection with human immunodeficiency virus 1 (HIV-1) affects fibrosis development in patients infected with Schistosoma mansoni, we evaluated schistosomiasis-induced pathology in the ... -
Short report: Childhood coinfections with plasmodium falciparum and Scistosoma mansoni result in lower percentages of activated T cells and T regulatory memory cells than Schistosomiasis only
(University of NairobiSchool of Public Health, 2009-08)Flow cytometric analyses were performed to evaluate HLA-DR (+) activated T lymphocytes (Tact; CD3 (+)/CD4 (+)/CD25(medium)) and T regulatory cells (Treg; CD3 (+)/CD4(+)/CD25(high)) in the circulation of children 8-10 years ... -
Correlation between eosinophils and protection against reinfection with Schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humans.
(University of NairobiCollege of Health Science, 2006-04)Longitudinal investigations of an adult male population of Kenyan car washers who have heavy and quantifiable occupational exposure to Schistosoma mansoni cercariae revealed that some individuals develop resistance to ... -
Higher percentages of circulating mast cell precursors correlate with susceptibility to reinfection with Schistosoma mansoni.
(University of NairobiCollege of Health Sciences, 2006-12)A high level of serum IgE is generally associated with human resistance to schistosomes, though the protective mechanisms of IgE remain undefined. We recently reported that whereas some individuals who are occupationally ... -
T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.
(University of NairobiCollege of Health Science, 2007-10)Schistosomiasis mansoni is usually a chronic infection that leads to long-term, systemic exposure to schistosome antigens. Experimental Schistosoma mansoni infection is associated with immunoregulatory mechanisms, including ... -
Reduced susceptibility to praziquantel among naturally occurring Kenyan isolates of Schistosoma mansoni
(University of NairobiCollege of Health Science, 2009-08)BACKGROUND: The near exclusive use of praziquantel (PZQ) for treatment of human schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes. METHODOLOGY/PRINCIPAL FINDINGS: We measured ... -
Human papillomavirus infection and cervical abnormalities in Nairobi, Kenya, an area with a high prevalence of human immunodeficiency virus infection.
(University of NairobiCollege of Health Science, 2008-05)Human papillomavirus (HPV) infection and cervical abnormalities, and their association with human immunodeficiency virus (HIV) infection were studied in 488 women who visited a health center in Nairobi. PCR-based HPV and ... -
Influence of exposure history o the immunology and development of resistance to human Schistosomiasis mansoni
(University of NairobiCollege of Health Science, 2010-03)BACKGROUND: Previous studies suggest that humans can acquire immunity to reinfection with schistosomes, most probably due to immunologic mechanisms acquired after exposure to dying schistosome worms. METHODOLOGY/PRINCIPAL ... -
The life history and in vivo culture of Coelomomyces utahensis (Blastocladiomycetes).
(University of NairobiCollege of Health Science, 2009-01)Coelomomyces utahensis is a fungal parasite of several genera of mosquitoes that inhabit rock-pools in southern Utah. Studies of the biology of Coelomomyces and their potential use in biological control of mosquitoes have ... -
Circulating CD23+ B cell subset correlates with the development of resistance to Schistosoma mansoni reinfection in occupationally exposed adults who have undergone multiple treatments.
(University of NairobiCollege of Health Science, 2009-01)BACKGROUND: Elevated immunoglobulin E (IgE) levels are often associated with resistance to reinfection in human schistosomiasis. However, Although B cells are the source of schistosome-specific IgE, little is known about ... -
Increases in levels of schistosome-specific immunoglobulin E and CD23 (+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with schistosoma mansoni.
(University of NairobiCollege of Health Science, 2010-08)BACKGROUND: Age prevalence curves for areas in which schistosomiasis is endemic suggest that humans develop partial immunity to reinfection beginning in early adolescence. We conducted a 2-year longitudinal study to ... -
Outcome and haemato-toxicity of two chemotherapy regimens for childhood non-Hodgkin's lymphoma in a Kenyan hospital
(Department of Paediatrics, College of Health Sciences, University of Nairobi., 2009)BACKGROUND: Effectiveness and toxicity of childhood cancer treatments have never been evaluated in Kenya since introduction of structured care in the early seventies. OBJECTIVE: To evaluate effectiveness and ... -
Evaluation of urine CCA assays for detection for detection of Schistosoma mansoni infection in Western Kenya
(University of NairobiCollege of Health Science, 2011-01)Although accurate assessment of the prevalence of Schistosoma mansoni is important for the design and evaluation of control programs, the most widely used tools for diagnosis are limited by suboptimal sensitivity, slow ... -
Association of the gene polymorphisms IFN-gamma +874, IL-13 -1055 and IL-4 -590 with patterns of reinfection with Schistosoma mansoni.
(University of NairobiCollege of Health Science, 2009)BACKGROUND: The immunologic findings that most consistently correlate with resistance in human schistosomiasis are high levels of IgE and low levels of IgG4. We have genotyped gene and promoter polymorphisms of cytokines ... -
Identification of cytokeratin 18 as a biomarker of mouse and human hepatosplenic schistosomiasis.
(University of NairobiCollege of Health Science, 2011-02)Previously, we demonstrated unique protein expression patterns in 20-week-Schistosoma mansoni-infected CBA/J mice with moderate splenomegaly syndrome (MSS) or hypersplemomegaly syndrome (HSS). To better understand the ... -
The hyperimmunoglobulin E syndrome--a neutrophil chemotactic defect reversible by histamine H2 receptor blockade?
(College of Health Sciences, University of Nairobi, 1980) -
Schistosomiasis among young children in Usoma, Kenya
(University of NairobiCollege of Health Science, 2011-05)Although schistosomiasis burden is greatest among school-age children (SAC) (6-15 years of age), infection among preschool-age children (PSAC) (1-5 years), may be underestimated in endemic areas. We conducted a cross-sectional ... -
Geographical distribution of schistosomiasis and soil-transmitted helminths among school children in informal settlements in Kisumu City, Western Kenya.
(University of NairobiSchool of Public Health, 2011-10)This cross-sectional study determined the prevalence and distribution of schistosome and soil-transmitted helminth (STH) infections among 1,308 children aged 10-18 years in 34 primary schools in 8 informal urban settlements ... -
Practical therapeutics: psychotherapy.
(KMADepartment of Pyschiatry, 1984) -
You cannot prevent a disease; you only treat diseases when they occur: knowledge, attitudes and practices to water-health in a rural Kenyan community.
(University of NairobiSchool of Public HealthSchool of Public Health, 2011-06)OBJECTIVE: Almost 1 billion individuals lack access to improved water supplies, with 2.6 billion lacking adequate sanitation. This leads to the propagation of multiple waterborne diseases. The objective of this study was ...
