Faculty of Health Sciences (FHS): Recent submissions
Now showing items 3021-3040 of 10418
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Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase.
(University of NairobiFaculty of medicine, 2000-05)The pH optima of family 11 xylanases are well correlated with the nature of the residue adjacent to the acid/base catalyst. In xylanases that function optimally under acidic conditions, this residue is aspartic acid, whereas ... -
Dissecting the electrostatic interactions and pH-dependent activity of a family 11 glycosidase.
(University of NairobiFaculty of medicine, 2001)Previous studies of the low molecular mass family 11 xylanase from Bacillus circulans show that the ionization state of the nucleophile (Glu78, pK(a) 4.6) and the acid/base catalyst (Glu172, pK(a) 6.7) gives rise to its ... -
Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model.
(University of NairobiFaculty of medicine, 2007)Various nature-mimicking pyranones such as 6-(2,5-dimethylfuran-3-yl)-pyran-2-one and 6-(furan-2-yl)-pyran-2-one derivatives were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded ... -
Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles.
(University of NairobiFaculty of medicine, 2007)Parasitic diseases such as malaria, leishmaniasis, and trypanosomiasis represent a significant global burden and pose a great challenge to drug discovery and delivery scientists due to their intracellular nature and ... -
Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery.
(University of NairobiFaculty of medicine, 2007)The objective of this investigation was to develop solid lipid nanoparticles (SLN) of tretinoin (TRE) with the help of facile and simple emulsification-solvent diffusion (ESD) technique and to evaluate the viability of an ... -
Investigation of monovalent and bivalent enantioselective molecular recognition by electrospray ionization-mass spectrometry and tandem mass spectrometry.
(University of NairobiFaculty of medicine, 2008)In this work is described the investigation of bivalent versus monovalent enantioselective molecular recognition in the context of enantioselective separations. Electrospray ionization-mass spectrometry (ESI-MS) and tandem ... -
Lipid nanoparticles for parenteral delivery of actives.
(University of NairobiFaculty of medicine, 2008)The present review compiles the applications of lipid nanoparticles mainly solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid drug conjugates (LDC) in parenteral delivery of pharmaceutical ... -
Synthesis of alpha-amyrin derivatives and their in vivo antihyperglycemic activity.
(University of NairobiFaculty of medicine, 2008)Ficus racemosa belongs to the family of Moraceae and is commonly known as 'Gular' in north India. Bio-activity guided isolation work on the fruits of F. racemosa resulted in the identification of antidiabetic active ... -
Direct targeting of the mucin 1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells.
(University of NairobiFaculty of medicine, 2009)The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed by approximately 90% of human breast cancers. However, there are no effective agents that directly inhibit MUC1 and induce death of breast cancer cells. We have ... -
MUC1-C oncoprotein functions as a direct activator of the nuclear factor-kappaB p65 transcription factor.
(University of NairobiFaculty of medicine, 2009)Nuclear factor-kappaB (NF-kappaB) is constitutively activated in diverse human malignancies. The mucin 1 (MUC1) oncoprotein is overexpressed in human carcinomas and, like NF-kappaB, blocks cell death and induces transformation. ... -
MUC1 oncoprotein is a druggable target in human prostate cancer cells.
(University of NairobiFaculty of medicine, 2009-11)Human prostate cancers are dependent on the androgen receptor for their progression. The MUC1 heterodimeric oncoprotein is aberrantly overexpressed in prostate cancers; however, it is not known if MUC1 is of functional ... -
Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer.
(University of NairobiFaculty of medicine, 2009)Signal transducer and activator of transcription 1 (STAT1) is activated in the inflammatory response to interferons. The MUC1 oncoprotein is overexpressed in human breast cancers. Analysis of genes differentially expressed ... -
Discolouration of Restorative Materials by beverages
(School of Dental Sciences, 1999) -
Biocompatible microemulsions for fabrication of glyceryl monostearate solid lipid nanoparticles (SLN) of tretinoin.
(University of NairobiFaculty of medicine, 2009-08)The objective of the present investigation was to fabricate glyceryl monostearate SLN by employing a biocompatible microemulsion as a template. Biocompatible excipients such as Tween 20 (as a surfactant) and Transcutol P ... -
MUCIN 1 Oncoprotein Expression Is Suppressed By The Mir-125b Oncomir.
(University of NairobiFaculty of medicine, 2010)The MUC1 oncoprotein is overexpressed in most human breast cancers by mechanisms that are incompletely understood. The microRNA, miR-125b, is downregulated in breast cancer cells. The present studies demonstrate that the ... -
Androgen receptor regulates expression of the MUC1-C oncoprotein in human prostate cancer cells.
(University of NairobiFaculty of medicine, 2011)The MUC1 heterodimeric oncoprotein is aberrantly overexpressed in human prostate cancers with more aggressive pathologic and clinical features. However, the signals that regulate MUC1 expression in prostate cancer cells ... -
Traditional health practitioners and mental health in Kenya
(Department of Psychiatry, 2008) -
Isocratic liquid chromatographic method for the analysis of roxithromycin and structurally related substances in bulk samples
(University of NairobiDepartment of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Nairobi., 2001)A selective, repeatable, and robust isocratic liquid chromatographic method has been developed for the analysis of bulk samples of roxithromycin, a semi-synthetic macrolide antibiotic. The method involves the use of XTerra ... -
Mental health policy and resources 'International Perspectives on Mental Health'
(Department of Psychiatry, 2011) -
Anti-Inflammatory and Anti-Diarrhoeal Activities of a Steroidal Indoxyl
(University of NairobiDepartment of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Nairobi., 2003)The anti-inflammatory and antidiarrhoeal activities of 3β-Hydroxy-16, 17-seco-16-nor-5-androsten-15-(2-indoxyliden)-17-oic acid (I) are reported. After intraperitoneal administration, compound (I) gave an ED50 of 9.5 mg/kg ...
