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Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians.

Madan, K; Batra, Y; Gupta, SD; Chander, B; Rajan, KD; Tewatia, MS; Panda, SK; Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2006)

AIM: To evaluate the clinical and biochemical profile of patients with non alcoholic fatty liver disease (NAFLD) and to assess their histological severity at presentation. METHODS: Consecutive patients presenting to the ...

Management of multiple intrahepatic recurrences after radiofrequency ablation of hepatocellular carcinoma with rhenium-188-HDD-lipiodol

Kumar, A; Bal, C; Srivastava, DN; Thulkar, SP; Sharma, S; Acharya, KS; Duttagupta, S (Department of Medicine, College of Health Sciences, University of Nairobi, 2006)

We tried to evaluate the role of dosimetry-guided transarterial radionuclide therapy (TART) with rhenium-188 (Re-188)-4-hexadecyl 1-2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol (HDD)-lipiodol in a patient with multiple ...

High affinity mouse-human chimeric Fab against hepatitis B surface antigen.

Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2005)

AIM: Passive immunotherapy using antibody against hepatitis B surface antigen (HBsAg) has been advocated in certain cases of Hepatitis B infection. We had earlier reported on the cloning and expression of a high affinity ...

Generation and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen

Bose, B; Khanna, N; Acharya, KS; Sinha, S (Department of Medicine, College of Health Sciences, University of Nairobi, 2006)

BACKGROUND: Antibody against hepatitis B surface antigen (HBsAg) is used for passive immunotherapy in certain cases of hepatitis B infection. The authors have earlier reported a high-affinity mouse monoclonal (5S) against ...

Oral health knowledge, attitudes and practices of parents/guardians of pre-school children in Moshi, Tanzania

Rwakatema, DS; Ng’ang’a, PM (University of Nairobi,Department of dental science,, 2009)

Objective: To assess the oral health knowledge, attitudes and practices of the parents/guardians of pre-school children in Moshi, Tanzania. Design: Cross-sectional study. Setting: Moshi Municipality, Kilimanjaro region, ...

Kaposis sarcoma in a Nairobi Hospital

Onyango JF.; Njiru A. (University of Nairobi,College of Health Sciences,, 2004-03)

Background: Kaposi's sarcoma (KS) is associated epidemiologically with HIV infection and a number of countries have reported a dramatic increase in the incidence of KS with the advent of AIDS. Although AIDS is prevalent ...

squamous cell carcinoma arising in a dentigerous cyst lining

Awange, DO (University of Nairobi,College of Health Sciences,, 2008)

A 33 year old presented with a cystic lesion of the maxilla which, on clinical and radiological grounds, was thought to be a dentigerous cyst associated with an un- erupted right maxillary third molar. The lesion was treated ...

Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens.

Sugiyama, M; Tanaka, Y; Kato, T; Orito, E; Ito, K; Acharya, KS; Gish, RG; Kramvis, A; Shimada, T; Izumi, N; Kaito, M; Miyakawa, Y; Mizokami, M (Department of Medicine, College of Health Sciences, University of Nairobi, 2006)

Various genotypes of the hepatitis B virus (HBV) induce liver disease of distinct severity, but the underlying virological differences are not well defined. Huh7 cells were transfected with plasmids carrying 1.24-fold the ...

Hepatitis E virus: epidemiology, diagnosis, pathology and prevention.

Acharya, KS; Panda, SK (Department of Medicine, College of Health Sciences, University of Nairobi, 2006)

HEV, a positive stranded RNA virus, is responsible for most of the epidemics of hepatitis in the developing world and is transmitted through contaminated water. It is the major aetiological agent for acute hepatitis and ...

HBV treatment: the hazy endpoint

Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2006)

Viral hepatitis in India

Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2006)

Viral hepatitis is a major public health problem in India, which is hyperendemic for HAV and HEV. Seroprevalence studies reveal that 90%-100% of the population acquires anti-HAV antibody and becomes immune by adolescence. ...

Management of gastric variceal bleeding

Javvaji, S; Kumar, A; Madan, K; Garg, PK; Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2007)

Evaluating patients with cirrhosis for hepatocellular carcinoma: value of clinical symptomatology, imaging and alpha-fetoprotein.Oncology

Paul, SB; Gulati, MS; Sreenivas, V; Madan, K; Gupta, AK; Mukhopadhyay, S; Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2007)

OBJECTIVE: This study was undertaken to assess the value of clinical symptomatology, abdominal ultrasound (US), triple-phase CT (TPCT) and serum alpha-fetoprotein (AFP) estimation in predicting presence of hepatocellular ...

Incidence of hepatocellular carcinoma among Indian patients with cirrhosis of liver: an experience from a tertiary care center in northern India

Paul, SB; Sreenivas, V; Gulati, MS; Madan, K; Gupta, AK; Mukhopadhyay, S; Panda, SK; Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2007)

BACKGROUND/AIM: Despite bearing the main burden of HCC, prospective studies from developing countries are lacking. This prospective observational study was designed to estimate the incidence of HCC among Indian patients ...

Acral and palmo-plantar hyperpigmentation in a patient with disseminated hepatocellular carcinoma

Goyal, R; Chalamalasetty, SB; Madan, K; Paul, SB; Arora, R; Safaya, R; Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2007)

Capecitabine (5-fluorouracil prodrug) is being evaluated for the management of hepatocellular carcinoma, and is associated with a peculiar skin reaction called hand and foot syndrome (HFS). We describe one patient with HCC ...

Role of surface promoter mutations in hepatitis B surface antigen production and secretion in occult hepatitis B virus infection

Acharya, KS (Department of Medicine, College of Health Sciences, University of Nairobi, 2007)

The production, secretion, and localization of surface proteins of hepatitis B virus (HBV) and the ratio of large to small surface protein S was studied in HepG2 cells transfected with the wild-type and mutant pre-S1 and ...