Faculty of Health Sciences (FHS): Recent submissions
Now showing items 9821-9840 of 10418
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Burkitt's lymphoma and emerging therapeutic strategies for EBV and Aids-associated lymphoproliferative diseases in East Africa
(Department of Haematology and Blood Transfusion, College of Health Sciences. University of Nairobi. Nairobi. Kenya, 2005)In 1958, Denis Burkitt was the first to describe a reticulum cell sarcoma of the jaw in children at the Mulago Hospital and Makerere University Scbool of Medicine in Kampala, Uganda, which was later determined to be a ... -
Congenital afibrogenaemia in a Kenyan child: case report.
(Department of Human Pathology, College of Health Sciences, University of Nairobi,Haematology and Blood Transfusion, Department of Human Pathology, University of Nairobi, College of Health Sciences,, 2010-02)Congenital afibrinogenaemia (CA), is a rare inherited bleeding disorder characterised by complete deficiency of fibrinogen in the plasma. Blood clotting tests are indefinitely prolonged in patients. Themode of inheritance ... -
Chédiak-Higashi syndrome: a case report on an African infant.
(1990-09)An African Kenyan female infant was born with very light skin and ashen grey, scanty hair. At 18 months she presented with a bluish skin pigmentation, hepatosplenomegaly, generalised lymphadenopathy and non-responsive ... -
Acute lymphocytic leukaemia complicating the course of hodgkin's disease-a case report of a kenyan african and review of the literature
(1979-10)This is a case report of a 12-year-old male who developed acute lymphocytic leukaemia (ALL) 8 years after a diagnosis of Hodgkin's disease (HD) had been made. During the 8 years, intensive radiotherapy and a single dose ... -
Absence of HIV seropositivity in children with sickle cell anaemia at Kenyatta National Hospital, Nairobi, Kenya.
(Department of Paediatrics, University of Nairobi, Nairobi, Kenya, 1987)OBJECTIVE: To find out whether frequent blood transfusions increase the risk of transfusion-related HIV infection in children with Sickle cell anaemia. METHODS: One hundred and ninety-eight children with Sickle cell anaemia ... -
The role of needle aspiration cytology in the differential diagnosis of accessible paediatric tumours
(, Department of Human Pathology and Consultant Haematologist , Kenyatta National Hospital, 1989-03)In the period 1985-88, 171 fine needle aspirates from paediatric patients with malignant and non-neoplastic masses were processed and evaluated in the Department of Haematology, Kenyatta National Hospital, Nairobi. Sixty-five ... -
Aspects of epidemiological and clinical features of patients with central nervous system burkitt's lymphoma in Kenya
(Department of Haematology and Blood Transfusion, College of Health Sciences, University of Nairobi, 2004)Background: Establishing characteristics of Central nervous System (CNS) Burkitt's lymphoma (BL) is essential as CNS disease is associated with poor treatment outcome. Objective: To document the characteristics of those ... -
Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses
(Department of Community Health, University of Nairobi, Nairobi, Kenya, 2008)Background: The host immune response against mucosally acquired pathogens may be influenced by the mucosal immune milieu during acquisition. As Neisseria gonorrhoeae can impair dendritic cell and T-cell immune function, ... -
Anatomical site predilections of non-hodgkin's lymphoma in human immunodeficiency virus infection:a report on 54 cases.
(Department of Haematology and Blood Transfusion, College of Health Sciences, University of Nairobi, 2004)Objective: To identify and describe the primary anatomic sites of non-Hodgkin's lymphoma arising in the setting of Human Immunodeficiency Virus infection. Design: Prospective (ongoing) study. Setting: Kenyatta National ... -
Monthly antibiotic chemoprophylaxis and incidence of sexually transmitted infections and HIV-1 infection in Kenyan sex workers: a randomized controlled trial.
(Department of MedicaL MicrobioLogy, College of HeaLth Sciences, University of Nairobi, Nairobi, Kenya, 2004-06)CONTEXT: Sexually transmitted infections (STIs) are common in female sex workers (FSWs) and may enhance susceptibility to infection with human immunodeficiency virus type 1 (HIV-1). OBJECTIVE: To examine regular ... -
AIDS-associated cancer in developing nations
(ColIege of Health Sciences, University of Nairobi, Nairobl, Kenya, 2004)Purpose of review With the emergence of the highly active antiretroviral therapy era, It is apparent that the Incidence of Kapost sarcoma, in particular, and lymphoma In patients with AIDS is declining, especially In ... -
Lack of efficacy of isoniazid chemoprophylaxis in the preventions of tuberculosis in hiv - 1 infected adults
(Department of Community Health, University of Nairobi, 2008)Background: Six months of daily isoniazid has been shown to be effective in preventing tuberculosis in the pre-HIV era. Because of underlying immune dysfunction and increased susceptibility to new infection this efficacy ... -
Adult burkitt's lymphoma in patients with and without human immunodeficiency virus infection in kenya
(Department of Haematology and Blood Transfusion, College of Health Sciences, University of Nairobi, 2001)Prior to the acquired immunodeficiency syndrome (AIDS) epidemic, one or two cases of adult Burkitt's lymphoma (BL) were seen annually at the Kenyatta National Hospital, the national referral medical center in Nairobi, ... -
Acute aflatoxicosis:
(Department of Clinical Pharmacology, College of Health Sciences, University of Nairobi, 2005)The objective of this presentation is to document the salient clinical findings in a case of aflatoxicosis and to review the literature on the same so as to increase the index of suspicion, enhance early diagnosis and ... -
Closing in on Immune Protection in the Women of Pumwani
(Department of Community Health, University of Nairobi, 1995)This review provides the reader with pertinent information on the epidemiology, prevention, and new technologies of the ongoing HIV pandemic. These aspects are key to international policy discussions surrounding the public ... -
Latent TB detection by interferon gamma release assay (IGRA) in pregnancy predicts active TB and mortality in HIV-1 infected women and their children
(6Department of Paediatrics, University of Nairobi, Nairobi, Kenya, 2010)Background—We evaluated the prognostic utility of interferon-gamma release assays (IGRAs) for active tuberculosis (TB) and mortality in Kenyan HIV-1 infected women and their infants. Methods—Prevalence and correlates of ... -
Reduced rates of HIV acquisition during unprotected sex by Kenyan female sex wo kers predating population declines in H IV prevalence
(Departments of Medical Microbiology, Community Health, University of Nairobi, 2008)OBJECTIVES: Female sex workers (FSWs) form a core group at high risk of both sexual HIV acquisition and secondary transmission. The magnitude of these risks may vary by sexual risk taking, partner HIV prevalence, host ... -
Mushroom polysaccharide extracts delay progression of carcinogenesis in mice
(2006)Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in ... -
Management of vulvar melanoma and review of the literature.
(2007)BACKGROUND: Vulvar melanoma represents a rare group of malignancies and is the second most common vulvar malignancy. Treatment options range from local excision of the tumor and sentinel lymph node dissection to radical ... -
Predictors of early mortality in a cohort of human immunodeficiency virus Type 1-infected African Children
(Department of Pediatrics, University of Nairobi, Nairobi, Kenya, 2004)Background: Pediatric human immunodeficiency virus type 1 (HIV-1) infection follows a bimodal clinical course with rapid progression in 10–45% of children before the age of 2 years and slower progression in the remainder. ...
