A comparative study of bioavailabity of brands of acetylsalicylic acid tablets from different manufacturers

Abstract

The project was intended to compare relative bioavailabilities f 4 brands of acetylsalicylic acid tablets as well as to establish ether a correlation exists between in-vitro dissolution rate and inary excretion analysiso The official chemical analysis of the tablets showed that I the tablets contained amounts of acetylsalicylic acid within le required official limitso I The B.P. method of obtaining disintegration times of the lblets was adopted and the brands had a rank order of: C ~astest rate), D,B,Ao The dissolution profiles of the 4 brands was obtained employing the rotating basket method (U.S.P). The rank order sed on the rate of drug release ran as: B{most superior), D,C, The in-vivo(urinary excretion) analysis was conducted urine sampleso These samples were periodically obtained from catheterized. male rabit. The rank order of bioavailability was tained after~y)compu ing th7 area under the curve in the plot cumulative amount of drug excreted versus timeo The order s: B(highest% bioavailability),D,C,A. The in-vitro dissolution rates were found to correlate th the in-vivo results. No correlation could be established tween in-vitro dissolution rates and disintegration times.