Solid Pseudopapillary Neoplasm of the Pancreas

Abstract

Solid pseudopapillary neoplasm is a rare pancreatic tumour predominantly affecting young women. We present two cases in young female patients. Both tumours were surgically removed as abdominal masses, one from the pancreatic tail and the other posterior to the stomach with an unclear organ of origin. On gross examination, both tumours were encapsulated with solid and cystic cut surfaces that had hemorrhage and necrosis. On histological examination, both were composed of solid sheets and pseudopapillae lined by bland, monotonous and uniform round cells. One tumour had features of malignancy. Immunohistochemistry for both cases was consistent with solid pseudopapillary neoplasm. Solid pseudopapillary neoplasm should be considered in the differential in young women presenting with pancreatic masses.