Clinical pulmonary adenomatosis of sheep produced experimentally.

Abstract

A preparation of ovine adenomatous lung produced clinical pulmonary adenomatosis in seven out of ten sheep inoculated intratracheally. They showed dyspnoea, occasional cough and watery discharge through the nostrils in varying degrees. The earliest symptoms occurred 150 days after inoculation. Typical adenomatous lesions were observed, ranging from the earliest foci, located in thickened interalveolar septa, to sheets of cuboidal and columnar cells. An eighth sheep also had gross adenomatous lesions but no typical symptoms 120 days after infection. Neither fibroplasia, lymphoreticular hyperplasia, nor metastasis to regional lymph nodes was encountered. The results support the view that the disease is a transmissible lung tumour. It can be differentiated from the many other conditions mistakenly referred to as pulmonary adenomatosis