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    Effect of Provitamin A-biofortified Cassava on Vitamin A Status of Kenyan Children: A Randomised Controlled Trial

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    Date
    2015-08-14
    Author
    Talsma1, Elise F
    Brouwer, Inge D
    Verhoef, Hans
    Mwangi4, Alice M
    Boy, Erick
    Maziya-Dixon, Busie B
    Zimmermann, Michael B.
    Melse-Boonstra, Alida
    Type
    Article; en
    Language
    en
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    Abstract
    Objectives: To measure the effect of daily consumption of provitamin A-biofortified cassava on vitamin A status in children aged 5-13 years. Methods: Mild-to-moderate vitamin A deficient children (n=342) were randomly allocated to groups receiving: 1) 375 g of white cassava and placebo supplement; 2) 375 g of white cassava and a supplement of β-carotene (1,054 μg); 3) 375 g of biofortified cassava and placebo supplement. Children received the intervention 6 days/week for 18.5 weeks. Field staff and participants were blinded to supplementation. Cooked cassava was mashed with salt and 4 g of oil per portion. Biofortified cassava supplied 208 μg RAE, which is ~50% of the age-specific estimated average requirement for vitamin A for children. The primary endpoint was serum retinol concentration and secondary endpoint was serum β-carotene concentration, both at end of intervention; in the analysis, we adjusted for sex and serum concentrations at baseline of retinol, C-reactive protein and α1-acid-glycoprotein. Results: Complete data were collected for 337 children. Compliance to cassava feeding was similar between treatment groups. Preliminary results showed that consumption of biofortified cassava and β-carotene supplementation resulted in a similar increase in retinol concentrations (for both interventions, mean: 0.81 μmol/L versus 0.77 μmol/L; difference, 95% CI: 0.04 μmol/L, 0.00─0.07 μmol/L) but in a different increase in serum β-carotene concentration (for β-carotene supplement group, mean: 0.25 μmol/L (95% CI: 0.17─0.33), for biofortified cassava group, mean: 0.81 μmol/L (95% CI: 0.73-0.88)) Conclusions: Provitamin A-biofortified cassava improves the vitamin A status of primary school children in Kenya.
    URI
    http://hdl.handle.net/11295/91348
    Citation
    Talsma, E. F., Brouwer, I. D., Verhoef, H., Mwangi, A. M., Boy, E., Maziya-Dixon, B. B., ... & Melse-Boonstra, A. (2015). Effect of Provitamin A-biofortified Cassava on Vitamin A Status of Kenyan Children: A Randomised Controlled Trial. EJNFS, 5(5): 836-837,
    Publisher
    University of Nairobi
    Collections
    • Faculty of Agriculture & Veterinary Medicine (FAg / FVM) [5481]

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