Positive α1-Foetoprotein Tests in Pyridoxine Deprived Baboons: Relevance to Liver Carcinoma in Africans

Abstract

A PREVIOUS report1 has described significant histological changes occurring in the livers of baboons that had been deprived of pyridoxine for periods of five months to three years. It was suggested that these changes might be “pre-neoplastic” and that specific dietary deficiencies, could be involved—as well as plant or chemical carcinogens or other unknown factors—in the reported high incidence of primary carcinoma of the liver in Africans.