Investigation Of The Effects Of Excess Ethylenediamine On The Chemical Stability Of Aminophylline Injections
Abstract
Aminophylline injections contain theophylline combined with ethylenediamine in a 2:1 ration and the injections are used for various purposes
(9, 10, 12) - The official compedia specify the addition of
ethylendiamine in excess of that required to form the aminophylline.
This is supposedly to ensure that any slight carbon dioxide absorption
does not precipitate theophilline which is only slightly/(15). A / soluble
farther role to that is that the excess ethyl enerii amine could in fact •
chemically stabilise the aminopylline, that is decrease chemical
degradition of aminophylline. This project was an investigation of
that possible role.
Aminophilline injections were assayed '^determine both the quantities
of ethylendiamine and theopylline and hence the content of excess
ethylenediamine. The assay included solutions made in 0.01N NaOH
and in boratebuffer and percentage recovery determined. The various
theophylline solutions including the injections were examined by
thin layer chromatography (TLC). Differential spectroscopy work was
also carried out and finally the degradation kinetics at boiling
point of water (94.60 C
; of pure theophylline and the aminopylline
injections studied.
Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
The following license files are associated with this item: