The Effect Of Amodiaquine On Some Autonomically Innervated Organs

Abstract

Amodiaquine is a aminoquinoline used in treatment of Malaria. In the present work, the drug was observed to cause myocardial depression on an isolated rabbit heart even in presence of cardiastiraulatory doses of adrenaline. The heart rate decreased whereas the coronary flow rate was slightly affected. These effects were shown to be antagonised by adrenaline which is a known antidote to chloroquine poisoning. A similar experiment was done where amodiaquine was 2.* observed to antagonise 8a induced guinea-pig ileum contractioi The action of amodiaquine was dose-dependent and could be due to an overall non-specific spasmolytic activity on the membrane! On the phrenic nerve-diaphragm preparation, the drug had a concentration-dependent dual action. The action of amodiaquii was antagonised by phyanstigndne in this case. Various drugs known to induce parturition and which act on an isolated rat uterus were observed to be antagonised by amodiaquine. The drug caused contractions which depending on the drug, required various doses of amodiaquine to abolish.