Comparative Evaluation of Sucrose and Povidone as Binders for Sodium Salicylate Tablet Formulations

Abstract

This project was particularly intended for comparison of effectiveness and suitability of two different binders namely sucrose and povidone on the tablet characteristics and physical stability with time. The wet granulation method was employed in making of the tablets where the active ingredient was sodium salicylate. The finished batches were subjected to both official [Disintegration, Dissolution] and non official tests [mechanical strength, friability, Thickness and Diameter], initially and three months after production. These tests gave a guideline in comparison of the two binders' suitability. Disintegration times and dissolution rates are test parameters for which prediction of drug plasma levels can be estimated, if they are the RATE-LIMITING steps, then the in-vitro results are expected to correlate with in-vivo test results. Mechanical strength and Friability testing give an idea on the suitability of tablet characteristics for convenience of handling in transportation and in use. Diameter and thickness testing is necessary for patient's compliance and tablet identification. The project showed that povidone had better binding properties than sucrose.