Pterocarpans and isoflavones from the root bark of millettia micans and of millettia dura
Date
2016Author
Marco, M
Deyou, T
Gruhonjic, A
Holleran, JP
Duffy, S
Heydenreich, M
Fitzpatric, PA
Landberg, G
Koch, A
Derese, S
Pelletier, J
Avery, VM
Erdélyi, Máté
Yenesew, A
Language
enMetadata
Show full item recordAbstract
From the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia micans, a new pterocarpan,
(6aR,11aR)-7,8,9-trimethoxy-3-hydroxypterocarpan (1), named micanspterocarpan, was isolated. Similar
investigation of the CH2Cl2/CH3OH (1:1) extract of the root bark of Millettia dura gave a further new pterocarpan,
3-O-prenylmaackiain (2) along with six known isoflavones (3-8) and a chalcone (9). All purified
compounds were identified by NMR and MS, and the absolute configuration of 1 was established by quantum
chemical CD calculation. The isolated constituents, calopogonium isoflavone B (3) and isoerythrin A-4'-
(3-methylbut-2-enyl) ether (4) showed marginal activities against the 3D7 and the Dd2 strains of Plasmodium
falciparum (70-90% inhibition at 40
URI
https://profiles.uonbi.ac.ke/sderese/publications/pterocarpans-and-isoflavones-root-bark-millettia-micans-and-millettia-durahttp://hdl.handle.net/11295/97953
Citation
Marco M, Deyou T, Gruhonjic A, Holleran JP, Duffy S, Heydenreich M, Fitzpatric PA, Landberg G, Koch A, Derese S, Pelletier J, Avery VM, Erdélyi Máté, Yenesew A. "Pterocarpans and Isoflavones from the Root Bark of Millettia micans and of Millettia dura." Advances in Drug Discovery and Development. 2016: 1-8.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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