Genital inflammation predicts HIV-1 shedding independent of plasma viral load and systemic inflammation

dc.contributor.author	Blish, Catherine A.
dc.contributor.author	McClelland, R. Scott
dc.contributor.author	Richardson, Barbra A
dc.contributor.author	Jaoko Walter G.
dc.contributor.author	Mandaliya, Kishorchandra
dc.contributor.author	Baeten, Jared M
dc.contributor.author	Overbaugh, Julie
dc.date.accessioned	2013-02-14T12:17:13Z
dc.date.available	2013-02-14T12:17:13Z
dc.date.issued	2012
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/22878424
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9888
dc.description.abstract	In women, genital HIV-1 RNA levels predict the risk of HIV-1 transmission independent of plasma viral load. To better understand the factors that contribute to genital HIV-1 shedding, we evaluated the relationships between genital and plasma cytokine concentrations and HIV-1 RNA levels. Vaginal, but not plasma, levels of interferon gamma-induced protein 10 (IP-10) were significantly associated with vaginal viral load, independent of plasma viral load. Thus, efforts to decrease HIV-1 transmission must take into account the role of local inflammation, which is not necessarily reflected in plasma measurements.	en
dc.language.iso	en	en
dc.subject	HIV-1,	en
dc.subject	Inflammation,	en
dc.subject	Cytokine,	en
dc.subject	Genital,	en
dc.subject	Shedding,	en
dc.subject	Transmission	en
dc.title	Genital inflammation predicts HIV-1 shedding independent of plasma viral load and systemic inflammation	en