University of Nairobi Institutional Repository: Recent submissions
Now showing items 65821-65840 of 116514
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1973-University sets the pace
(Daily Nation, 1973) -
1970-University plans vital role in society
(Daily Nation, 1970) -
1973-University pays homage to 'great man of our time'
(Daily Nation, 1973) -
1973-University may accept external degree courses
(Daily Nation, 1973) -
1972-University management clarifies B.A jobs situation
(Daily Nation, 1972) -
1980-Journalist among the 2,000 who received degrees and diplomas
(Daily Nation, 1980) -
1980-Graduation ceremony
(Daily Nation, 1980) -
1979-Educate people on their rights
(Daily Nation, 1979) -
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes
(College of Biological and Physical Sciences ,Department of physics, 2012)Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ... -
OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance
(College of Biological and Physical Sciences ,Department of physics, 2012)OSI-930, a dual c-Kit and KDR tyrosine kinase inhibitor, is reported to have undergone a Phase I dose escalation study in patients with advanced solid tumors. A series of fifteen pyridyl and phenyl analogues of OSI-930 ... -
CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900
(College of Biological and Physical Sciences ,Department of physics, 2012)We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ... -
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
(College of Biological and Physical Sciences ,Department of physics, 2012)Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data ... -
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes
(College of Biological and Physical Sciences ,Department of physics, 2013)Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ... -
How do novel molecular genetic markers influence treatment decisions in acute myeloid leukemia?
(College of Biological and Physical Sciences ,Department of physics, 2012)Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults, and the majority of patients with AML die from relapsed disease. Although many studies over the past 4 decades have identified disease ... -
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia
(College of Biological and Physical Sciences ,Department of physics, 2013)Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ... -
African programme: kenya.
(Department of Ophthalmology, University of Nairobi, 2000) -
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
(College of Biological and Physical Sciences ,Department of physics, 2013)Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ... -
Hydrologic Analysis For River Nyando Using SWAT
(University of NairobiDepartment of Meteorology, 2011)The Nyando River is one of the major Rivers in the Lake Victoria Basin. It drains parts of Nandi, Kericho and Nyando districts. It has a catchment area of about 3600km−2 of Western Kenya and an average discharge of ... -
More on normal prothrombin times in the presence of therapeutic levels of rivaroxaban - early experience from King's College Hospital
(College of Biological and Physical Sciences ,Department of physics, 2013) -
Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies
(College of Biological and Physical Sciences ,Department of physics, 2013)
