The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group.
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Date
1996Author
Brunham, RC
Kimani, J
Bwayo, J
Maitha, G
Maclean, I
Yang, C
Shen, C
Roman, S
Nagelkerke, NJ
Cheang, M
Plummer, FA
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Female sex workers in Nairobi were prospectively evaluated for risk factors of incident Chlamydia trachomatis infection. Independent risk factors included cervical ectopy (P=.007), gonococcal infection (P=.002), human immunodeficiency virus (HIV) seropositivity (P=.003), HIV seroconversion (P=.001), and duration of prostitution (P=.002). Eighteen different C. trachomatis outer membrane protein (omp1) genotypes were identified, with the allelic composition of the C. trachomatis population changing significantly over time (P=.005). Seventeen of 19 reinfections > or = 6 months apart were with different C. trachomatis omp1 genotypes. Women with HIV infection had an increased proportion of visits with C. trachomatis infection (P=.001) and an increased risk of reinfection (P=.008). Overall, the data demonstrate significant fluctuations in the genotype composition of the C. trachomatis population and a reduced rate of same-genotype reinfection consistent with the occurrence of strain-specific immunity.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57721http://www.ncbi.nlm.nih.gov/pubmed/8603976
Publisher
University of Nairobi College of Health Science
Collections
- Faculty of Health Sciences (FHS) [10378]