Faculty of Health Sciences (FHS): Recent submissions
Now showing items 10301-10320 of 10418
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Mechanism of action of cathinone: the active ingredient of khat (catha edulis)
(2000)Objective: To review the current understanding of the mechanism of action of cathinone, the active ingredient of khat. Data source: Published experimental studies on the nature and action and effect of cathinone on the ... -
Knowledge, Perception, Practice of Atraumatic Restorative Treatment Among Nairobi-based Dentists
(2006)Objectives: To determine the knowledge, perception and practice of Atraumatic restorative treatment among dentists in Nairobi. Methods: A descriptive cross-sectional study in which questionnaires with the relevant ... -
Indications for initial placement and replacement of amalgam and composite restorations
(2011)The aim of this study was to establish the reasons for initial placement and replacement of dental amalgam and resin composite restorations. It was a cross-sectional descriptive study in which 253 respondents convenient ... -
Discolouration of teeth: an overview of the diagnosis and management.
(1995-04)The dentist is faced with a daunting task in application of clinical skills to achieve maximum cosmetic results when it comes to the management of discoloured and/or hypoplastic dentition. In this paper, an overview is ... -
Dimensional changes of resin/ionomer restoratives in aqueous and neutral media
(2000)OBJECTIVES: The aim was to study dimensional time-dependence of resin/ionomer formulations from 5 min age to one month and to separate out the intrinsic setting shrinkage and hygroscopic expansion effects, by using ... -
Triterpenoids From the Stem Bark of Blighia unijugata Bak. (Sapindaceae)
(2009)Two pentacyclic triterpenoids were isolated, for the first time, from the stem bark of Blighia unijugata Bak. The structures of the two compounds were elucidated on the basis of their spectral data as friedelin ... -
Drug Quality Control in Kenya: Observation in the Drug Analysis and Research Unit During the Period 2001-2005
(2008)During the five-year period January 2001 to December 2005, the Drug Analysis and Research Unit received and analyzed 394 drug samples. Samples were received from regulatory authorities, local industry, non-governmental ... -
A stability-indicating HPLC method for the separation of clarithromycin and related substances in bulk samples
(2001-11)Clarithromycin is a 6-O-methylated semi-synthetic derivative of erythromycin A, which is more resistant towards acid decomposition. Commercial clarithromycin samples contain several potential impurities arising from the ... -
A common CD4 gene variant Is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers
(2009)It has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has been found to be highly prevalent among Africans, changes the tertiary structure of CD4, which may alter susceptibility to ... -
It is time for evidence based community interventions in prevention
(Department of Ophthalmology, School of Medicine, University of Nairobi, 2007) -
Transmission intensity and the immunoepidemiology of bancroftian filariasis in East Africa
(2001)Previous attempts to determine the interactions between filariasis transmission intensity, infection and chronic disease have been limited by a lack of a theoretical framework that allows the explicit examination of ... -
The prevalence, clinical features, risk factors and outcome associated with cryptococcal meningitis in HIV positive patients in Kenya
(2010)To determine the prevalence, clinical features, risk factors and outcomes associated with cryptococcal meningitis (CM) in human immunodeficiency virus (HIV) positive patients at two referral hospitals in Nairobi, Kenya ... -
Antifungal Susceptibilities of Cryptococcus Neoformans Cerebrospinal fluid Isolates from AIDS Patients in Kenya
(2010)Poor susceptibility of Cryptococcus neoformans to fluconazole (FLC) is a matter of concern among clinicians in Africa. The emergence of resistance to FLC was recently reported in Kenya, but it is not known whether it is ... -
HIV-Exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors
(2010)Studies of human immunodeficiency virus (HIV)–exposed seronegative individuals are crucial to informvaccine design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce lower ... -
Clade specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 Clade A1 p24
(2009)HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains unknown. We ... -
Association between participant self-report and biological outcomes used to measure sexual risk behavior in HIV-1- seropositive female sex workers in Mombasa, Kenya
(2012)Few studies have examined the association between self-reported sexual risk behaviors and biologic outcomes in human immunodeficiency virus (HIV)-1-seropositive African adults. METHODS: We conducted a prospective cohort ... -
European and developing countries clinical trials partnership (EDCTP):
(2009)European and Developing Countries Clinical Trials Partnership (EDCTP) was founded in 2003 by the European Parliament and Council. It is a partnership of 14 European Union (EU) member states, Norway, Switzerland, and ... -
HIV-1 RNA Dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers
(2009)Subclinical endotoxemia has been reported in HIV-1 infected persons and may drive systemic immune activation and pathogenesis. Proinflammatory responsiveness to endotoxin (LPS) is mediated by Toll-like receptor 4 (TLR4). We ... -
Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection
(2008)Toll-like receptors (TLR) are important in pathogen recognition and may play a role in HIV disease. We evaluated the effect of chronic untreated and treated HIV-1 infection on systemic TLR expression and TLR signalling. ... -
An Integrated approach for antiretroviral adherence and secondary HIVtransmission risk-reductionsupport by nurses in Kenya
(2012)Ongoing antiretroviral therapy (ART) adherence and secondary HIV transmission-risk reduction (positive prevention) support are needed in resourcelimited settings.We evaluated a nurse-delivered counseling intervention ...
