Faculty of Health Sciences (FHS): Recent submissions
Now showing items 4621-4640 of 10418
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Identification of a novel HLA B*57 restricted cytotoxic T-lymphocyte epitope within HIV-1 rev
(University of Nairobi,College of Health Sciences,, 2006)HLA-B5701 and its related allele B5703 have been shown to be strongly associated with slow HIV-1 disease progression. To elucidate the effect of these alleles fully on disease progression it is essential to identify key ... -
Differences in HIV natural history among African and non-African seroconverters in Europe and seroconverters in sub-Saharan Africa.
(University of nairobiCollege of health science, 2012) -
Developing standards of care for HIV prevention research in developing countries -- a case study of 10 research centers in Eastern and Southern Africa.
(University of NairobiCollege of health science, 2012) -
Characterization of an HLA-C-restricted CTL response in chronic HIV infection
(University of Nairobi,School of health science, 2010-04)HIV-specific CTL play an important role in the host control of HIV infection. HIV-nef may facilitate escape of HIV-infected cells from CTL recognition by selectively downregulating the expression of HLA-A and HLA-B molecules, ... -
HLA-B*57 versus HLA-B*81 in HIV-1 Infection: Slow and Steady Wins the Race?
(University of NairobiCollege of Health Sciences, 2013) -
Is the baboon model appropriate for endometriosis studies?
(University of NairobiSchool of Health Sciences, 2011-09)No abstract available -
Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa
(Department of Human Pathology, 2010-09)Purpose of review: Ocular surface squamous neoplasia (OSSN) in sub-Saharan countries is an aggressive tumor that affects younger patients and appears to be increasing in incidence. There are data to suggest the association ... -
Abattoirs and echinococcosis in Nairobi dogs
(School of medicine, University of NairobiAfrican Medical and Research Foundation, (AMREF), 1994-04) -
Childhood Diarrhoea: Failing Conventional Measures, What Next?
(University of NairobiDepartment of Medical PhysioIology, 2011-08)BACKGROUND: Diarrhoea is one of the leading causes of infant mortality. This article analyzes its contribution towards the realization of millennium development goal number 4 (MDG-4). METHODS: A PubMed search using ... -
Overview Of Influenza Virus Infections In Kenya: Past, Present And Future
(Department of MedicalphysioIology, 2013-04)The World Health Organization (WHO) estimates that acute lower respiratory infections account for 4 million deaths per year. The rates are even higher in developing countries. Influenza, a virus causing respiratory infections, ... -
Gonococcal Cervicitis Is Associated With Reduced Systemic Cd8+ T Cell Responses In Human Immunodeficiency Virus Type 1-infected And Exposed, Uninfected Sex Workers.
(University of NairobiDepartment of Medical Microbiology, 2002)Neisseria gonorrhoeae cervicitis and human immunodeficiency virus (HIV) type 1 frequently coinfect core transmitter populations, such as female sex workers. Gonococcal cervicitis is associated with increased viral shedding ... -
Resistance to HIV-1 infection among highly exposed sex workers in Nairobi: what mediates protection and why does it develop?
(University of NairobiDepartment of Medical Microbiology, 1999-03)Variability in susceptibility to infection and disease caused by infectious agents is a characteristic of all populations. Among susceptible individuals exposed to an infection, not all become infected and among infected ... -
HLA typing in a Kenyan cohort identifies novel class I alleles that restrict cytotoxic T-cell responses to local HIV-1 clades.
(University of NairobiDepartment of Medical Microbiology, 2002-09)OBJECTIVES: To investigate HLA class I allele frequencies in a Kenyan commercial sex worker (CSW) cohort, and to examine HIV-1 specific cytotoxic T lymphocyte (CTL) responses directed against epitopes derived from locally ... -
Pattern of femoro-popliteal aneurysms in an African population
(Department of Human Anatomy, 2010-06)To describe the pattern of femoro-popliteal aneurysms in an African Kenyan population. Records of African in-patients with diagnosis of femoral or popliteal aneurysms admitted at the Kenyatta National Hospital, Nairobi, ... -
Characterization Of Protein-protein Interactions Between The Nucleocapsid Protein And Membrane Protein Of The Sars Coronavirus.
(University of NairobiDepartment of Medical Microbiology, 2004-10)The human coronavirus, associated with severe acute respiratory syndrome (SARS-CoV), was identified and molecularly characterized in 2003. Sequence analysis of the virus indicates that there is only 20% amino acid (aa) ... -
Vasa Vasora in the tunica media of goat aorta
(Department of Human Anatomy, 2011)This study aimed at describing the distribution of vasa vasora in the tunica media of various parts of goat aorta, since this influences the physico-mechanical properties and disease occurrence. Specimens were obtained ... -
Novel Interferon Regulatory Factor-1 Polymorphisms In A Kenyan Population Revealed By Complete Gene Sequencing
(University of NairobiDepartment of Medical Microbiology, 2004)Variation in susceptibility to HIV-1 infection depends on numerous factors, and host genetic variation has been well-described as an important component. As a transcriptional regulator, interferon regulatory factor 1 (IRF-1) ... -
Cd4+ T Cell Responses In Hiv-exposed Seronegative Women Are Qualitatively Distinct From Those In Hiv-infected Women
(University of NairobiDepartment of Medical Microbiology, 2005-01)The immune response of human immunodeficiency virus (HIV)-exposed seronegative (ESN) women may be qualitatively different from that in those infected with HIV (HIV(+)). In a cohort of female commercial sex workers in ... -
Misclassification of Plasmodium infections by conventional microscopy and the impact of remedial training on the proficiency of laboratory technicians in species identification
(Department of Biochemistry, 2013)Malaria diagnosis is largely dependent on the demonstration of parasites in stained blood films by conventional microscopy. Accurate identification of the infecting Plasmodium species relies on detailed examination of ... -
Elevated T Cell Counts And Rantes Expression In The Genital Mucosa Of Hiv-1-resistant Kenyan Commercial Sex Workers.
(University of NairobiDepartment of Medical Microbiology, 2005-09)The initial site of exposure to human immunodeficiency virus (HIV)-1 during heterosexual transmission occurs in the genital tract. Although the majority of immunological studies have focused on the immune response to HIV-1 ...
