Faculty of Health Sciences (FHS): Recent submissions
Now showing items 9221-9240 of 10418
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The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis.
(2011-03)Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) ... -
Pattern and outcome of abdominal injuries at Kenyatta National Hospital, Nairobi.
(Department of Surgery, Moi Teaching and Referral Hospital,, 2006)To establish the pattern and results of interventions in patients with abdominal injuries requiring admission. A descriptive, prospective, hospital-based study involving observation of patients from admission to final ... -
High levels of cervical HIV-1 RNA during early HIV-1 infection.
(Department of Medical Microbiology, University of NairobiDepartment of Epidemiology, University of Washington, Seattle, Washington, USA, 2006)Few data are available on genital tract viral replication early after HIV-1 acquisition, when infectivity is high. We compared cervical HIV-1 RNA from 60 women with paired samples from within 90 days after HIV-1 acquisition ... -
Spinal tuberculosis among human immunodeficiency virus-negative patients in a Kenyan tertiary hospital: a 5-year synopsis.
(Department of Human Anatomy, School of Medicine, University of Nairobi,, 2011-04)BACKGROUND CONTEXT: Spinal tuberculosis (TB) accounts for more than half of all cases of skeletal TB. Although Kenya has one of the highest burdens of TB, data on spinal TB in this country remain scarce. PURPOSE: To ... -
Re: distinguishing the temporal association between women's intravaginal practices and risk of human immunodeficiency virus infection: a prospective study of South African women
(Department of Medical Microbiology, University of NairobiDepartment of Epidemiology, University of Washington, Seattle, WA 98104, USA, 2007)In their study of South African women's intravaginal practices and risk of human immunodeficiency virus (HIV) infection, Myer et al. (1) found a significant association between intravaginal practices and HIV serostatus at ... -
Predictors of functional recovery in African patients with traumatic intracranial hematomas
(Department of Neurosurgery, University of Nairobi, Nairobi, Kenya., 2011)Head injury is a critical public health problem responsible for up to 50% of fatalities among trauma patients and for a large component of continuing care among survivors. Intracranial hematomas are among the most common ... -
SOCS-1 mimetics protect mice against lethal poxvirus infection: identification of a novel endogenous antiviral system
(Department of Medicine. College of Health Sciences. University of Nairobi, 2009)The suppressor of cytokine signaling 1 (SOCS-1) protein modulates cytokine signaling by binding to and inhibiting the function of Janus kinases (JAKs), ErbB, and other tyrosine kinases. We have developed a small tyrosine ... -
Factors influencing the outcome of severe head injury at Kenyatta National Hospital.East
(Department of Surgery, Kenyatta National Hospital, University of Nairobi Medical School, Kenya., 2001)OBJECTIVE: To study the factors influencing the outcome of severe head injury. DESIGN: A retrospective study. SETTING: Kenyatta National Hospital, Nairobi, Kenya. SUBJECTS: Six hundred and seventy seven patients with ... -
Vertex Epidural Hematoma Manifesting with Bilateral Upper Limb Decerebrate Posture:
(Department of Surgery, College of Health Sciences, University of Nairobi, 2009)Vertex epidural haematomas (VEDH) are rare and difficulties are encountered in diagnosis and management. This is a case report of a patient with a vertex epidural haematoma who presented with signs of severe head injury ... -
High HIV prevalence, low condom use and gender differences in sexual behaviour among patients with STD-related complaints at a Nairobi primary health care clinic.
(Department of Microbiology, University of Nairobi, Kenya, 1997)Of 22,274 patients > or = 12 years old attending a Nairobi primary health care (PHC) clinic, 1076 (4.8%) had STD-related complaints, of whom 980 underwent assessment of risk factors for human immunodeficiency virus (HIV) ... -
Non-penetrating chest blows and sudden death in the young
(Department of Surgery, University of Nairobi, Nairobi, Kenya, 2000-11)Sudden death in the young after low energy anterior chest wall impact is an under-recognised phenomenon in this country. Review of the literature yields several American references to commotio cordis, mainly in the context ... -
Viral etiology and epidemiology of acute respiratory infections in children in Nairobi, Kenya.
(Department of Medical Microbiology, University of Nairobi, Kenya., 1998)Acute respiratory infection (ARI) is the most common cause of illness and death in young children worldwide. Because of inadequate laboratory facilities and financial resources the etiological agents responsible for most ... -
Antimicrobial prophylaxis in pregnancy: a randomized, placebo-controlled trial with cefetamet-pivoxil in pregnant women with a poor obstetric history
(World Health Organization Centre for Research and Training in Sexually Transmitted DiseasesDepartment of Medical Microbiology, University of Nairobi, Kenya., 1997)OBJECTIVE: This study was undertaken to measure the impact of a single oral dose of cefetamet-pivoxil on pregnancy outcome in a population with substantial rates of low birth weight and high prevalence rates of maternal ... -
Naturally occurring IgG anti-HLA alloantibody does not correlate with HIV type 1 resistance in Nairobi prostitutes
(Department of Immunology, University of Toronto, The Toronto Hospital, Canada.Department of Medical Microbiology, University of Nairobi, 1998)In an effort to identify an immunological basis for natural resistance to HIV-1 infection, we have examined serum antibody responses to HLA class I antigens in female prostitutes of the Nairobi Sex Workers Study. Anti-HLA ... -
Indoor air pollution in a Kenyan village.
(Department of Paediatrics, College of Health Sciences, University of Nairobi, Kenya., 1990)In April 1986, a study was carried out within rural households in Maragua area, Muranga District, Republic of Kenya, to assess the degree of indoor air pollution and to find its relationship, if any, to acute respiratory ... -
A review of the trends of lymphomas in the equatorial belt of Africa
(Department of Surgery, University of Nairobi, Nairobi, Kenya, 2011-09)Lymphomas represent one of the most frequent cancer types in Africa. In particular, approximately 30,000 non-Hodgkin lymphomas occur in the equatorial belt of Africa each year and these tumours are in among the top-ten ... -
Verbal autopsy: a tool for determining cause of death in a community.
(Department of Paediatrics, College of Health Sciences, University of Nairobi, Kenya., 1990)Verbal autopsy was used to determine causes of death in 239 children under the age of 5 years. The diagnosis derived from verbal autopsy was corroborated with hospital diagnosis in 39 cases. There was concurrence of diagnosis ... -
Effect of human immunodeficiency virus type 1 infection upon acute salpingitis: a laparoscopic study
(Department of Obstetrics and Gynecology, University of Washington, Seattle, USADepartment of Medical Microbiology, University of NairobiDepartment Obstetrics and Gynaecology, University of Nairobi, 1998)To determine the effect of human immunodeficiency virus type 1 (HIV-1) infection upon pelvic inflammatory disease (PID), a laparoscopic study of acute PID was conducted in Nairobi, Kenya. Subjects underwent diagnostic ... -
Mortality patterns in a rural Kenyan community.
(Department of Paediatrics, College of Health Sciences, University of Nairobi., 1990)Causes of death of 239 children below the age of 5 years in a rural community were determined using structured questionnaires. It was found that mortality was highest in infancy, accounting for 63% of all deaths with a ... -
Epidemiology of acute respiratory tract infections among young children in Kenya.
(Department of Paediatrics, University of Nairobi,, 1990)The epidemiology of acute respiratory tract infection (ARI) was investigated in a rural community 80 km north of Nairobi, Kenya. This research was conducted prospectively on 250 families with 470 children less than 5 years ...
