Faculty of Health Sciences (FHS): Recent submissions
Now showing items 9301-9320 of 10418
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Potential use of specific human and chicken antibodies for detection of Hanganutziu-Deicher antigen(s) in sera of cancer patients
(College of Health Sciences, University of Nairobi, 1994-10)A human Hanganutziu-Deicher (HD) antibody and a chicken anti-N-glycolyneuroaminyllactosylceramide (HD3) antibody were compared in their reaction against HD antigen-active ganglioside (HD3) and a glycoprotein (GP) by ... -
Immunogenicity of N-Glycolylneuraminic Acid-Containing Carbohydrate Chains of Recombinant Human Erythropoietin Expressed in Chinese Hamster Ovary Cells
(College of Health Sciences, University of Nairobi, 1995)Recombinant human erythropoietin (EPO) produced by Chinese hamster ovary cells and distributed by two different pharmaceutical companies were confirmed to contain about 1% N-glycolylneuraminic acid (Neu5Gc) in total sialic ... -
Implementing voluntary medical male circumcision for HIV prevention in Nyanza Province, Kenya: lessons learned during the first year
(Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois,Department of Medical Microbiology, University of NairobiNational AIDS and STI Control Programme, Nairobi, KenyaJohns Hopkins University Bloomberg School of Public Health, United States of AmericaNyanza Reproductive Health Society, Kisumu, Kenya, 2011)BACKGROUND: In 2007, the World Health Organization endorsed male circumcision as an effective HIV prevention strategy. In 2008, the Government of Kenya (GoK) launched the national voluntary medical male circumcision ... -
Evidence for a free N-acetylneuraminic acid-hydroxylating enzyme in pig mandibular gland soluble fraction
(College of Health Sciences, University of Nairobi, 1995-01-15)The activity of a free N-acetylneuraminic acid (Neu5Ac)-hydroxylating enzyme which converted Neu5Ac into N-glycolyl-neuraminic acid (Neu5Gc) was demonstrated in the soluble fraction of pig mandibular gland. The hydroxylation ... -
Establishment of a biobank and pharmacogenetics database of African populations
(Department of Medicine. College of Health Sciences. University of Nairobi, 2008-07)No abstract -
Acceptability of medical male circumcision among uncircumcised men in Kenya one year after the launch of the national male circumcision program
(Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IllinoisDepartment of Medical Microbiology, University of Nairobi, 2011)BACKGROUND: Numerous studies have demonstrated that male circumcision (MC) reduces the incidence of the Type-1 human immunodeficiency virus (HIV) among heterosexual men by at least half. METHODS: One year after the ... -
Failure of human immunoresponse to N-glycolylneuraminic acid epitope contained in recombinant human erythropoietin
(College of Health Sciences, University of Nairobi, 1996)Recombinant human erythropoietin (rHUEPO) was produced by Chinese hamster ovary cells and commercially distributed to hospitals by two pharmaceutical companies in Japan ('ESPO' by Kirin Brewery Co. Ltd., and Sankyo Co. ... -
Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009.
(Division of Epidemiology and Biostatistics, University of Illinois at Chicago, ChicagoDepartment of Medical Microbiology, University of NairobiDepartments of Medical Microbiology, University of Manitoba, Winnipeg, CanadaBacteriology and Enteric Diseases Program, National Microbiology Laboratory Canadian Science Centre for Human and Animal Health, Winnipeg, CanadaUNIM Project, Kisumu, KenyaDivision of Infectious Diseases, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 2011)We evaluated antimicrobial resistance in Neisseria gonorrhoeae isolated from men enrolled in a randomized trial of male circumcision to prevent HIV. Urethral specimens from men with discharge were cultured for N. gonorrhoeae. ... -
Quality of antimalarial drugs analysed in the National quality control laboratory during the Period 2002
(Department of Medicine. College of Health Sciences. University of Nairobi, 2007)No abstract -
erum Hanganutziu and Deicher (HD) antibody and total sialic acid levels in hepatoma patients
(College of Health Sciences, University of Nairobi, 1998)A preliminary short follow-up study of Hanganutziu and Deicher (HD) antibody titre and sialic acid levels in sera from 7 patients with hepatoma was carried out. Weekly HD antibody titres were abnormal in 6 patients with ... -
Chloroquine Resistance: Proposed Mechanisms and Countermeasures
(2010-10)Malaria has been, and remains, one of the biggest global health concerns as far as infectious diseases are concerned, with yearly incidence and mortality figures running into millions. One of the major drawbacks to the ... -
Male circumcision is associated with a lower prevalence of human papillomavirus-associated penile lesions among Kenyan men.
(Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NCDepartment of Pathology, VU University Medical Center, Amsterdam, the NetherlandsDepartment of Biostatistics, Gillings School of Global Public Health, University of North, Carolina, Chapel Hill, NCImpact Research and Development Organization, Kisumu, KenyaDivision of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, ILDepartment of Medical Microbiology, University of Nairobi, 2012)Human papillomavirus (HPV)-associated penile lesions in men may increase the risk of HPV transmission to their female partners. Risk factor data on HPV-associated penile lesions are needed from regions with a high burden ... -
Total Sialic acid (TSA) and Hanganutziu and Deicher (HD) antibody in malignant and healthy sera
(College of Health Sciences, University of Nairobi, 2007-05)OBJECTIVE: To determine the levels of both TSA and HD antibody in sera of patients with various malignancies and evaluate their potential role as diagnostic and/ or prognostic markers. DESIGN: Laboratory based ... -
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
(Department of Medicine. College of Health Sciences. University of Nairobi, 2010-12)A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity. The Cu(I)-catalyzed cycloaddition of azides ... -
Circumcision preference among women and uncircumcised men prior to scale-up of male circumcision for HIV prevention in Kisumu, Kenya
(Nyanza Reproductive Health Society, Kisumu, KenyaDivision of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL, USADepartment of Research, Impact Research and Development Organization, Kisumu, KenyaDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya, 2012)Following the endorsement by the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) of male circumcision as an additional strategy to HIV prevention, initiatives to introduce safe, ... -
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones
(Department of Medicine. College of Health Sciences. University of Nairobi, 2010-02)A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity. The antimalarial data for this series suggests that growth inhibition of the W2 strain of Plasmodium falciparum can be imparted ... -
A pilot study of the feasibility of a vaginal washing cessation intervention among Kenyan female sex workers
(Department of Medical Microbiology, University of NairobiDepartment of Epidemiology, University of Washington, Seattle, Washington, USADepartment of Medicine, University of Washington, Seattle, Washington, USADepartment of Medicine, University of British Columbia, Vancouver, CanadaDepartment of Biostatistics, University of Washington, Seattle, Washington, USAFred Hutchinson Cancer Research Center, Seattle, Washington, USACollege of Nursing, New York University, New York, New York, USA, 2013)Background Intravaginal practices including vaginal washing have been associated with HIV-1 acquisition. This association may be mediated by mucosal disruption, changes in vaginal flora or genital tract inflammatory ... -
Frequency and magnitude of Chlamydia trachomatis elementary body- and heat shock protein 60-stimulated interferon gamma responses in peripheral blood mononuclear cells and endometrial biopsy samples from women with high exposure to infection.
(2009)Cellular immune responses characterized by interferon gamma (IFN-gamma) production enhance clearance and confer protective immunity against Chlamydia trachomatis infection but have not been simultaneously investigated in ... -
Loss to Follow-Up as a Competing Risk in an Observational Study of HIV-1 Incidence
(Departments of Medicine and Global Health, University of Washington, Seattle, Washington, United States of AmericaDepartment of Medical Microbiology, University of Nairobi, Nairobi, Kenya, 2013)OBJECTIVE: Conventional survival estimates may be biased if loss to follow-up (LTF) is associated with the outcome of interest. Our goal was to assess whether the association between sexual risk behavior and HIV-1 ... -
Immunoepidemiologic profile of Chlamydia trachomatis infection:Importance of Heat-Shock Protein 60 and Interferon-γ
(2005)Epidemiological, animal, and in vitro investigations suggest that Chlamydia trachomatis infection engenders acquired immunity, the basis for which is incompletely defined, especially in humans. In a prospective cohort study ...
