Now showing items 4861-4880 of 5481

    • Salmonella virulence factor SipB induces activation and release of IL-18 in human dendritic cells 

      Dreher, Donatus; Kok, Menno; Obregon, Carolina; Kiama, S G; Gehr, Peter; Nicod, Laurent P. (Division of Pneumology, University Hospital of Geneva, SwitzerlandDepartment of Genetics and MicrobiologyDepartment of Medical Biochemistry, University of Geneva, SwitzerlandInstitute of Anatomy, University of Berne, SwitzerlandDepartment of Veterinary Anatomy, University of Nairobi, Kenya, 2002)
      Interleukin-18 (IL-18) plays an important role in innate and acquired immunity, in particular against intracellular pathogens. However, little is known about the microbial factors that trigger IL-18 secretion by dendritic ...
    • Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18 

      Obregon, Carolina; Dreher, Donatus; Kok, Menno; Cochand, Laurence; Kiama, S G; Nicod, Laurent P. (Department of Veterinary Anatomy, University of Nairobi,Division of Pneumology, University Hospital of GenevaDepartment of Genetics and Microbiology, University of Geneva,, 2003)
      Recent publications have demonstrated that the protease caspase-1 is responsible for the processing of prointerleukin 18 (IL-18) into the active form. Studies on cell lines and murine macrophages have shown that the bacterial ...
    • Outcome mapping for fostering and measuring change in risk management behaviour among urban dairy farmers 

      Nyangaga, Julius N; Grace, Delia; Kimani, Violet; Kiragu, Monica W; Langat, Alfred K; Mbugua, Gabriel; Mitoko, Grace; Kang’ethe, Erastus K (SpringerInternational Livestock Research Institute,Department of Community Health, University of Nairobi,Ministry of Livestock Development, Nairobi, KenyaCentre for Microbiological Research, Kenya Medical Research Institute,Department of Public Health, Faculty of Veterinary Medicine, University of Nairobi,, 2012)
      A study was undertaken to investigate and mitigate the risk from zoonotic Cryptosporidium associated with dairy farming in Dagoretti division, Nairobi, Kenya. Outcome mapping (OM), a relatively new tool for planning and ...
    • Genetic background of attenuated Salmonella typhimurium has profound influence on infection and cytokine patterns in human dendritic cells 

      Dreher, Donatus; Kok, Menno; Cochand, Laurence; Kiama, S G; Gehr, Peter; Peche`, Jean-Claude; Nicod, Laurent Pierre (2001)
      Salmonella typhimurium (ST) can cause infection in man, and attenuated strains are under consideration as live vaccine vectors. However, little is known about the interaction of ST with human dendritic cells (DC). Here, ...
    • Observation of the pathology of natural eimeria infections in kids in Kenya 

      Githigia, S M; Munyua, W K; Kanyari, P W N (Department of Veterinary Pathology, Microbiology & Parasitology Faculty of Veterinary Medicine University of Nairobi, 1992-12)
    • Evaluation of phagocytic activity in human monocyte-derived dendritic cells 

      Kiama, S G; Cochand, L; Karlsson, L; Nicod, L P; Gehr, P (Institute of Anatomy, University of Berne, Berne, Switzerland.Division of Pneumology, University Hospital of Geneva, Geneva, Switzerland., 2001)
      Dendritic cells play a central role in initiation of primary T lymphocyte responses to foreign antigens. Their potency in antigen presentation vis-à-vis reported low or lack of ability to phagocytize particulate matter ...
    • Development and delivery of evidence-based messages to reduce the risk of zoonoses in Nairobi, Kenya 

      Kang’ethe, Erastus; Kimani, Violet; Grace, Delia; Mitoko, Grace; McDermott, Brigid; Ambia, Julie; Nyongesa, Concepta; Mbugua, Gabriel; Ogara, William; Obutu, Peninnah (SpringerDepartment of Public Health, Faculty of Veterinary Medicine, University of Nairobi,Department of Community Health, University of Nairobi,International Livestock Research Institute,Biometry Unit, Department of Crop Science, University of Nairobi,Centre for Microbiological Research, Kenya Medical Research Institute,, 2012)
      This paper describes a trans-disciplinary process of co-generating and disseminating evidence-based messages for reducing the risk from cryptosporidiosis and other zoonoses in an urban community in Nairobi. Research ...
    • Prospects and constraints facing women small-scale dairy farmers in Vihiga district, Western Kenya 

      Mugivane, F.I.; Ogara, W.O. (Department of Agricultural Economics, University of Nairobi, KenyaDepartment of Public Health, pharmacology and Toxicology, 2006-07)
      One of the major constraints to increased dairy production is lack of adequate feed. The Government of Kenya has encouraged the development of forage technology for adoption to address this constraint. The low adoption has ...
    • Participatory and integrative approaches to food safety in developing country cities 

      Grace, Delia; Kang’ethe, Erastus; Waltner-Toews, David (SpringerInternational Livestock Research Institute, Nairobi, KenyaDepartment of Public Health, Faculty of Veterinary Medicine, University of Nairobi,Veterinarians Without Borders, Victoria, Canada, 2012)
    • In vivo and in vitro effects of graded doses of the pesticide heptachlor on female sex steroid hormone production in rats 

      Oduma, J A; Wango, E O; Oduor-Okelo, D; Makawiti, D W; Odongo, H (Reproductive Biology Unit, University of NairobiDepartment of Veterinary Anatomy, University of Nairobi,Department of Biochemistry, University of Nairobi,, 1995)
      Adult female Sprague-Dawley rats were injected with corn oil or 5 mg, 20 mg, 25 mg or 30 mg per kg body weight of heptachlor solution every other day for up to 18 days. The rats were killed at the end of the experimental ...
    • Prevalence of cryptosporidiosis in dairy cattle, cattle-keeping families, their non-cattle-keeping neighbours and HIV-positive 

      Kange’the, Erastus; McDermott, Brigid; Grace, Delia; Mbae, Cecilia; Mulinge, Erastus; Monda, Joseph; Nyongesa, Concepta; Ambia, Julie; Njehu, Alice (tment of Public Health, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Nairobi,Biometry Unit, Department of Crop Science, University of Nairobi,International Livestock Research Institute,Centre for Microbiological Research, Kenya Medical Research Institute,, 2012)
      This paper reports a study estimating the prevalence of cryptosporidiosis, an emerging zoonosis, in people and cattle in Dagoretti, Nairobi. A repeated cross-sectional survey was carried out among randomly selected cattle ...
    • Isolation of e. coli 0157:h7 from milk and cattle faeces from urban dairy farming and non dairy farming neighbour households in Dagoretti division, Nairobi, Kenya: prevalence and risk factors 

      Kang'ethe, E K; Onono, J O; Mcdermott, B; Arimi, Samuel M (Department of Public Health, Pharmacology and Toxicology, 2007)
      Objective: To estimate the prevalence of E. coli 0157:H7 in milk and cattle faecal samples dairy and non dairy neighbouring households and to relate this prevalence to the risk to human health. Design: Cross sectional ...
    • Influence of organic and mineral fertilization on germination, leaf nitrogen, nitrate accumulation and yieldof vegetable amaranth 

      Onyango, Cecilia M.; Harbinson, Jeremy; Imungi, Jasper K.; Shibairo, Solomon I; Kooten, Olaf van (Taylor & Francis1Department of Plant Scienceand Crop Protection,Faculty ofAgriculture, University ofNairobi, Kangemi, Kenya2Department of Plant Sciences,Wageningen University, Wageningen, the Netherlands3Department of Food Science, Nutritionand Technology,Faculty ofAgriculture, University ofNairobi, Kangemi, Kenya, 2012)
      The influence of manure and diammonium phosphate (DAP) mineral fertilizer on germination, leaf nitrogen content, nitrate accumulation and yield of vegetable amaranth (Amaranthus hypochondriacus) was investigated.Field ...
    • Social and gender determinants of risk of cryptosporidiosis, an emerging zoonosis, in Dagoretti, Nairobi, Kenya 

      Kimani, Violet N; Mitoko, Grace; McDermott, Brigid; Grace, Delia; Ambia, Julie; Kiragu, Monica W; Njehu, Alice N; Sinja, Judith; Monda, Joseph G; Kang’ethe, Erastus K (Department of Community Health, University of Nairobi,Biometry Unit, Department of Crop Science, University of Nairobi,International Livestock Research Institute,Department of Public Health, Faculty of Veterinary Medicine,, 2012)
      The aim of the study was to investigate the social and gender determinants of the risk of exposure to Cryptosporidium fromurban dairying in Dagoretti, Nairobi. Focus group discussions were held in six locations to obtain ...
    • Cryptosporidium species detected in calves and cattle in Dagoretti, Nairobi, Kenya 

      Kang’ethe, Erastus K; Mulinge, Erastus K; Skilton, Robert A; Njahira, Moses; Monda, Joseph G; Nyongesa, Concepta; Mbae, Cecilia K (Department of Public Health, Pharmacology and Toxicology, Faculty of Veterinary MedicineCentre for Microbiology Research,Bioscience eastern and central Africa-International Livestock Research Institute Hub (BecA-ILRI Hub),Nairobi, Kenya, 2012)
      A total of 1,734 cattle faecal samples from 296 dairy-keeping households were collected from urban settings in Nairobi, Kenya. Modified Ziehl–Neelsen staining method and an immunofluorescence assay were used to identify ...
    • The multiple burdens of zoonotic disease and an ecohealth approach to their assessment 

      Grace, Delia; Gilbert, Jeff; Randolph, Thomas; Kang’ethe, Erastus (2012)
      Zoonoses occur at the interface of human and animal disease and partly because their impact and management fall across two sectors they are often neglected. The Global Burden of Disease captures the impact of zoonoses on ...
    • Strategies for the Prevention and Control of Highly Pathogenic Avian Influenza (HPAI) in Eastern Africa 

      Nyaga, P N (Department of Veterinary Pathology, Microbiology & Parasitology Faculty of Veterinary Medicine University of Nairobi, 2009-08)
      Although Uganda has many wetlands and lies on the migratory flyway for birds flying from Siberia through the Middle East and moving along the great Rift Valley to Southern Africa, it has not yet experienced avian influenza ...
    • Prevalence, intensity and spectrum of helminths of free range pigs in Homabay District, Kenya. 

      Ng’ang’a, C J; Githigia, S M; Maingi, N; Obonyo, F O (Department of Veterinary Pathology, Microbiology & Parasitology Faculty of Veterinary Medicine University of Nairobi, 2012)
      A cross-sectional study was conducted to determine the prevalence, intensity and spectrum of helminths of free range pigs in Homabay District, Kenya. Faecal samples from 372 pigs were examined using the modified McMaster ...
    • Knowledge of Mange among Masai Pastoralists in Kenya 

      Alasaad, S; Mijele, D; Ogara, W; Muchemi, G; Maingi, N; Heukelbach, J; Ombui, J; Gakuya, F (Department of Veterinary Pathology, Microbiology & Parasitology Faculty of Veterinary Medicine University of NairobiDepartment of Public Health Pharmacology and Toxicology, University of Nairobi, Kenya, 2012-08)
      Background: Pastoralists in low-income countries usually live in close proximity to their animals and thus represent an important repository of information about livestock disease. Since wild and domestic animals often ...
    • Risk factors associated with occurrence of nematodes in free range pigs in Busia District, Kenya 

      Gachohi, J W; Ng’ang’a, J C; Maingi, N; Githigia, S M; Kanyari, P N; Kagira, J M (Department of Veterinary Pathology, Microbiology & Parasitology Faculty of Veterinary Medicine University of Nairobi, 2012)
      Nematode infections are a serious constraint to pig production, especially where free range pig keeping is practiced. This study investigated the epidemiology of nematodes in free range pigs in Busia District, Kenya. Three ...