Browsing Faculty of Science & Technology (FST) by Author "Yenesew, Abiy"
Now showing items 1-20 of 55
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3-Hydroxyisoflavanones from the stem bark of Dalbergia melanoxylon: Isolation, antimycobacterial evaluation and molecular docking studies
(University of Nairobi, 2013-11)Two new 3-hydroxyisoflavanones, (S)-3,4′,5-trihydroxy-2′,7-dimethoxy-3′-prenylisoflavanone (trivial name kenusanone F 7-methyl ether) and (S)-3,5-dihydroxy-2′,7-dimethoxy-2″,2″-dimethylpyrano[5″,6″:3′,4′]isoflavanone ... -
3-Hydroxyisoflavanones From The Stem Bark Of Dalbergia Melanoxylon: Isolation, Antimycobacterial Evaluation And Molecular Docking Studies
(University of Nairobi, 2013)Two new 3-hydroxyisoflavanones, (S)-3,4′,5-trihydroxy-2′,7-dimethoxy-3′-prenylisoflavanone (trivial name kenusanone F 7-methyl ether) and (S)-3,5-dihydroxy-2′,7-dimethoxy-2″,2″-dimethylpyrano[5″,6″:3′,4′]isoflavanone ... -
4′-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species
(University of Nairobi, 2014)The CH2Cl2/MeOH (1:1) extract of the stem bark of Millettia oblata ssp. teitensis showed antiplasmodial activity (IC50 = 10–12 μg/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium ... -
6-Methoxycalpogonium Isoflavone A: A New Isoflavone from the Seed Pods of Millettia dura
(University of NairobiDepartment of Chemistry, University of Nairobi, 1997-08)From the seed pods of Millettia dura a new isoflavone has been isolated and identified as 3-(4-methoxyphenyl)-6-methoxy-8,8-dimethyl-4H,8H-benzo[1,2-b:3,4-b‘]dipyran-4-one (trivial name 6-methoxycalopogonium isoflavone A). ... -
6α-Hydroxy-α-toxicarol and (+)-tephrodin with antiplasmodial activities from Tephrosia species
(Elsevier, 2014)The CH2Cl2/MeOH (1:1) extract of the roots of Tephrosia villosa showed good antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values ... -
8-Hydroxy-6-methylxanthone-1-carboxylic acid and 6',8-O-dimethylknipholone from the roots of Bulbine frutescens
(University of Nairobi, 2014)Phytochemical investigation of the dichloromethane/methanol (1:1) extract of the roots of Bulbine frutescens led to the isolation of a new xanthone, 8-hydroxy-6-methylxanthone-1-carboxylic acid (1) and a new phenylanthraquinone, ... -
8-Methoxyneorautenol and radical scavenging flavonoids from Erythrina abyssinica
(Department of Chemistry, University of NairobiDepartment of Chemistry, Makerere UniversityInstitut für Chemie, Universität Potsdam, Germany, 2009)A new pterocarpan (named 8-methoxyneorautenol) was isolated from the acetone extract of the root bark of Erythrina abyssinica. In addition, the known isoflavonoid derivatives eryvarin L, erycristagallin and shinpterocarpin ... -
Alkaloids of Teclea nobilis
(University of NairobiCollege of Biological and Physical Sciences, 1988)A new furoquinoline alkaloid to which we have assigned the trivial name nobiline, and seven other quinonline alkaloids were isolated and identified from the leaves and fruits of Teclea nobilis, an African medicinal plant. -
Anthraquinones and chemotaxonomy of the asphodelaceae
(University of NairobiDepartment of Chemistry, Addis Ababa UniversityCollege of Biological and Physical Sciences,University of Nairobi, 1994)Phytochemical investigations on three genera of the Asphodelaceae, Aloe, KniphoJla and Bulbine showed that 1-methyl-8-hydroxyanthraquinones and anthrone-C-glycosides are characteristic constituents of the genus Aloe, ... -
Anthraquinones of the roots of Pentas micrantha
(University of NairobiDepartment of Chemistry, 2012-12)Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 ... -
An anthrone, an anthraquinone and two oxanthrones from Kniphofia foliosa
(University of NairobiCollege of Biological and Physical Sciences, 1994)The compounds isoknipholone, isoknipholone anthrone, foliosone and isofoliosone were isolated from the stem of Kniphofia foliosa and their structures determined by spectral analyses. In addition, the known compounds, ... -
Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia
(University of Nairobi, 2014-03)The surface exudates of the leaves of Dodonaea angustifolia from Ngong forest population (6 km from Nairobi city center, Kenya) demonstrated antimicrobial activity against Gram-negative (Escherichia coli), Gram-positive ... -
Antiparasitic and anticancer carvotacetone derivatives of Sphaeranthus bullatus.
(University of NairobiDepartment of Chemistry, 2012-09)The CH2Cl2-MeOH (1:1) extract of the aerial parts of Sphaeranthus bullatus, an annual herb native to tropical East Africa, showed activity against chloroquine sensitive D6 (IC50 9.7 microg/mL) and chloroquine resistant W2 ... -
Antiplasmodial and Antimicrobial Activities of Ent- Abietane Diterpenoids From the Roots of Suregada Zanzibariensis
(University of Nairobi, 2022)The root extract ofSuregada zanzibariensisBaill. afforded six previ-ously describedent-abietane diterpenoids, namely 7-oxo-ent-abieta-5(6),8(14),13(15)-trien-16,12-olide (1), mangiolide (2),8,14b:11,12a-diepoxy ... -
Antiplasmodial and cytotoxic activities of the constituents of turraea robusta and turraea nilotica
(University of Nairobi, 2015-08)Ethnopharmacological relevance Turraea robusta and Turraea nilotica are African medicinal plants used for the treatment of a wide variety of diseases, including malaria. The genus Turraea is rich in limonoids and other ... -
Antiplasmodial and larvicidal flavonoids from Derris trifoliata
(Department of Chemistry, University of Nairobi,School of Biological Sciences, University of NairobiUnited States Army Medical Research Unit-Kenya, MRU 64109, APO, AE 09831-4109, USADepartment of Chemistry, Makerere University, P.O. Box 7062, Kampala, UgandaInstitut für Chemie, Universität Potsdam, P.O. Box 60 15 53, D-14415 Potsdam, Germany, 2009)From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone ... -
The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii
(Department of Chemistry, University of NairobiUnited States Army Medical Research Unit-Kenya, Walter Reed Project, USASchool of Bio-Sciences, College of Natural Sciences, Makerere University, UgandaDepartment of Chemistry, Makerere University, UgandaCenter for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI)Department of Chemistry and Life Science, United States Military Academy, USA, 2012-08)The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of ... -
Antiplasmodial Flavonoids from Erythrina sacleuxii
(University of NairobiDepartment of Chemistry, University of NairobiDepartment of Chemistry, Maseno University, 2006-02)The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic ... -
Benzo[ b]naphtho[2,1- d]furans and 2-Phenylnaphthalenes from Streblus usambarensis
(University of Nairobi, 2023)Three new benzo[b]naphtho[2,1-d]furans, usambarins A-C (1-3), five new 2-phenylnaphthalenes, usambarins D-H (4-8), a new flavan (9), and a new phenyl-1-benzoxepin (10) as well as two known compounds (11 and 12) were isolated ... -
Benzo[ b]naphtho[2,1- d]furans and 2-Phenylnaphthalenes from Streblus usambarensis
(University of Nairobi, 2023)Three new benzo[b]naphtho[2,1-d]furans, usambarins A-C (1-3), five new 2-phenylnaphthalenes, usambarins D-H (4-8), a new flavan (9), and a new phenyl-1-benzoxepin (10) as well as two known compounds (11 and 12) were isolated ...
