Faculty of Health Sciences (FHS): Recent submissions
Now showing items 2141-2160 of 10417
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Caring for children with acute, treatable and preventable medical conditions
(University of Nairobi,, 2010)Parents perceive quality paediatric nursing care and interpersonal interactions between nurses, children and their parents/ guardians as caring. This article explores the nature and extent of nurse–parent/guardian interaction ... -
Neurobiology of Khat (Catha edulis Forsk)
(2014-03-17)Around 20 million individuals in eastern Africa and the Arabian Peninsula chew the fresh leaves and twigs of Catha edulis Forsk (khat) for its pyschostimulatory effect, a practice deeply rooted in their traditions and ... -
Assessment of the Feasibility of a Different HIV Vaccine Approach
(University Of Nairobi, 2011)Background: The failure of Merck STEP and Phambili trials and the modest effect of RV144 trial emphasize the importance of understanding the correlates of protective immunity. Our study showed that the epitope recognition ... -
Overview of Neglected Tropical Diseases and Conditions of the Nervous System: Past, Present and Perspectives
(2014)Neglected tropical diseases consist of a group of infectious diseases with the unifying features of being poverty-related, prevalent in tropical and subtropical regions, and absent from the public health agenda in wealthy ... -
Reflections On The First Pan- African Conference On Biochemistry And Molecular Biology
(University of Nairobi, 1997-04) -
Selection and Optimization of a Mucosal Sampling Method for Application in Phase 1 Clinical Trials
(University Of Nairobi, 2013)Background: An efficacious preventive HIV vaccine will likely require induction of immune responses at mucosal surfaces. One approach is to deliver vaccines intra-nasally. A pilot study was performed in Rwanda and Kenya ... -
Some African Vignettes
(University of Nairobi, 2000)In a continent where life expectancy at birth is as low as 38 years in some communities it may come as a surprise to discover that a few people do live beyond the age of 90. This paper is a collection of vignettes of the ... -
Prevalence and causes of vision loss in sub-Saharan Africa: 1990–2010
(University of Nairobi,, 2014)Aim To estimate the magnitude, temporal trends and subregional variation in the prevalence of blindness, and moderate/severe vision impairment (MSVI) in sub-Saharan Africa. Methods A systematic review was conducted of ... -
Visceral Leishmaniasis Unresponsive To Antimonial Drugs Iii. Successful Treatment Using A Combination Of Sodium Stibogluconate Plus Allopurinol
(University of Nairobi, 1985)Five patients with long-standing visceral leishmaniasis who were unresponsive to sodium stibogluconate, 20 mg antimony/kg body-weight once or twice daily, were treated for 14 to 54 days with a combination of sodium ... -
Estimated Risk Of Placental Infection And Low Birthweight Attributable To Plasmodium Falciparum Malaria In Africa In 2010: A Modelling Study.
(University of Nairobi, 2014)BACKGROUND: Plasmodium falciparum infection during pregnancy leads to adverse outcomes including low birthweight; however, contemporary estimates of the potential burden of malaria in pregnancy in Africa (in the absence ... -
Assessing the Role of Antigen-Specific CD8 + T Cells in Delayed Progression to AIDS
(University of Nairobi, 2013)Background: One major challenge in the development of an HIV- 1 vaccine is the extreme genetic diversity of the virus. A more cross-reactive T-cell response would be beneficial in cir- cumventing this issue, but many ... -
Compatibility Of Stabilized Whole Blood Products With Cd4 Technologies And Their Suitability For Quality Assessment Programs
(University of Nairobi, 2014)BACKGROUND: CD4 T cell enumeration is the most widely used prognostic marker for management of HIV disease. Internal quality control and external quality assessment (EQA) programs are critical to ensure reliability of ... -
Safety and Immunogenicity of a Candidate HIV-1 Vaccine,MVA.HIVA, Administered to Healthy Gambian Infants Born to HIV-1/2-Uninfected Mothers
(University of Nairobi, 2011-09)Background: The development of a safe and effective HIV-1 vaccine remains a global priority especially in prevention of mother to child transmission of HIV-1 during breastfeeding. Our vaccine platform consists of ... -
Clinical Characteristics Associated With Mycoplasma Genitalium Among Female Sex Workers In Nairobi, Kenya
(University of Nairobi, 2014)Prevalence of Mycoplasma genitalium is higher in vulnerable populations of women in low-resource settings. However the epidemiology of infection in these populations is not well established. To determine the prevalence of ... -
Hiv-1 Superinfection Is Associated With An Accelerated Viral Load Increase But Has A Limited Impact On Disease Progression.
(University of Nairobi, 2014)OBJECTIVE HIV-1 superinfection occurs frequently in high-risk populations, but its clinical consequences remain poorly characterized. We undertook this study to determine the impact of HIV-1 superinfection on disease ... -
Analysis of 100 African Whole Genome Sequences for Natural Host Resistance to HIV-1 Infection
(University of Nairobi, 2013)Background: HIV-1 exposed seronegative individuals (HESN) have been documented in diverse cohorts. Recent genome-wide studies capturing common genetic variation in European populations failed to identify HESN-associated ... -
The Expression Analysis of Glucose Transporter 1 Gene in the Pumwani Commercial Sex Worker Cohort, Nairobi, Kenya
(University of Nairobi, 2013)Background: Altered susceptibility to HIV1 infection has been observed in multiple cohort studies. One of the best characterized HIV1 exposed yet uninfected groups is a commercial sex worker cohort from Nairobi, Kenya. ... -
Immunogenicity of Homologous and Heterologous Regimens of Ad26-Enva.01 and Ad35-Enva HIV Vaccines in HIV- Uninfected Volunteers in the U.S. and Africa
(University of Nairobi, 2013)Background: Heterologous prime boost vaccine regimens offer a promising approach to improving T cell and antibody responses. Homologous and heterologous prime boost regimens were compared using two low seroprevalence ... -
Mucosal specimen collection, processing and assay - Experience from a resource-limited setting in Kenya
(University of Nairobi, 2013)Background: HIV-1 infection occurs most commonly through sexual intercourse. Induction of mucosal immune responses will likely be necessary for an effective HIV vaccine. KAVI embarked on building capacity for mucosal ... -
Assessing The Ability Of Health Information Systems In Hospitals To Support Evidence-informed Decisions In Kenya.
(University of Nairobi, 2014-07)BACKGROUND: Hospital management information systems (HMIS) is a key component of national health information systems (HIS), and actions required of hospital management to support information generation in Kenya are ...
