Faculty of Health Sciences (FHS): Recent submissions
Now showing items 4721-4740 of 10418
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Prevalence and severity of periodontal disease: type 2 diabetics versus non-diabetics.
(University of NairobiSchool of Dental Sciences, 2009-03)OBJECTIVE: To compare the periodontal status of a group of diabetic Coloured and Black communities of South Africa with a non-diabetic group. STUDY DESIGN: Sixty-seven type 2 diabetics (mean age: 49.3 +/- 8.97) and 67 ... -
A pilot quasi-experimental study to determine the feasibility of implementing a partograph e-learning tool for student midwife training in Nairobi
(School of Nursing Sciences, University of NairobiJean McFarlane Building, University of Manchester, ManchesterEast, Central and Southern African Health Community, Arusha, TanzaniaDepartment of Maternal, Newborn, Child & Adolescent Health, World Health Organization, 2013-03)Objective the partograph is a tool used globally to record labour progress. Although it has the potential to improve maternal and neonatal outcomes, some midwives struggle with using it in practice. Training in partograph ... -
Traumatic fistula resulting from sexual violence: a case study in Kenya
(University of NairobiFaculty of medicine, 2011-10-21)Gender-based violence is any violence that exploits distinctions between individuals of different sexes. Sexual violence in the form of rape or mass rape is traumatic for the victim but can have significant physical ... -
The Shaping Of Modern Human Immune Systems By Multiregional Admixture With Archaic Humans
(University of NairobiDepartment of Medical Microbiology, 2011)Whole genome comparisons identified introgression from archaic to modern humans. Our analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system components subject to strong balancing selection, ... -
HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis.
(University of NairobiDepartment of Medical Microbiology, 2004-10-21)The prospective significance of HIV-specific cytotoxic T lymphocyte (CTL) responses in highly exposed, persistently seronegative populations is unknown. In 1996-1997 we screened for CTL responses against HIV clade B Env ... -
Reduced Hiv-1 Long Terminal Repeat Transcription In Subjects With Protective Interferon Regulatory Factor-1 Genotype: A Potential Mechanism Mediating Resistance To Infection By Hiv-1.
(University of NairobiDepartment of Medical Microbiology, 2010-05)We previously described the polymorphism in the interferon regulatory factor-1 (IRF-1) gene as a novel correlate of resistance to HIV-1 infection in a Kenyan female sex worker cohort. However, the underlying mechanisms ... -
Barriers to contraceptive use in two areas of Kenya: rural (Bungoma district) and urban (Baba Dogo, Nairobi).
(University of Nairobi,Department of Obstetrics & Gynaecology,, 1993)his paper examines the barriers to contraceptive use of couples from an urban low socioeconomic community (Bungoma district) and a rural population (Baba Dogo, Nairobi) in Kenya. The study also explores the level of agreement ... -
European and Developing Countries Clinical Trials Partnership (EDCTP): the path towards a true partnership.
(University Of Nairobi.Department of MedicalMicrobiology, 2009-07)BACKGROUND: European and Developing Countries Clinical Trials Partnership (EDCTP) was founded in 2003 by the European Parliament and Council. It is a partnership of 14 European Union (EU) member states, Norway, Switzerland, ... -
Mucosal Serpin A1 And A3 Levels In Hiv Highly Exposed Sero-negative Women Are Affected By The Menstrual Cycle And Hormonal Contraceptives But Are Independent Of Epidemiological Confounders.
(University of NairobiDepartment of Medical Microbiology, 2013-01)OBJECTIVE: Serpins (serine protease inhibitors) are associated with protection against HIV infection. Here, we characterized mucosal serpin expression in the genital tract of HIV highly exposed sero-negative (HESN) women ... -
Effectiveness of chloroquine and sulfadoxine/pyrimethamine combination in the treatment of falciparum malaria in a malaria endemic area of Kenya
(Division of Vector Borne Diseases, Ministry of Health, P.O. Box 20750, Nairobi, KENYADepartment of Medical Microbiology, Faculty of Medicine, University of Nairobi, Box 19676, Nairobi, KENYADanish Bilharziasis Laboratory, Jaegersborg Alle ID, 2920 Charlottenlund, DANEMARKDepartment of Zoology, Kenyatta University, P.O. Box 43844, Nairobi, KENYA, 1998)A study on the comparative efficacy of two antimalarial drugs, namely chloroquine and sulfadoxine/pyrimethamine combination in the treatment of falciparum malaria was carried out in Siaya District, Nyanza Province of Kenya. ... -
Associations Of Human Leukocyte Antigen-g With Resistance And Susceptibility To Hiv-1 Infection In The Pumwani Sex Worker Cohort.
(University of NairobiDepartment of Medical Microbiology, 2013-01)OBJECTIVE: To determine the association between human leukocyte antigens (HLA)-G genotypes and resistance or susceptibility to HIV-1. DESIGN: A group of sex workers in Pumwani, Kenya can be epidemiologically defined ... -
Prevalence and types of coinfections in sleeping sickness patients in kenya (2000/2009).
(University of NairobiDepartment of Tropical Infectious Diseases, 2011)The occurrence of coinfections in human African trypanosomiasis (HAT) patients was investigated using a retrospective data of hospital records at the National Sleeping Sickness Referral Hospital in Alupe, Kenya. A total ... -
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial
(School of medicine, University of Nairobi, 2013)Summary Background Mobile (cell) phone communication has been suggested as a method to improve delivery of health services. However, data on the effects of mobile health technology on patient outcomes in resource-limited ... -
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol.
(University of NairobiDepartment of Medical Microbiology, 2009-09)BACKGROUND: The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy ... -
HLA-G And Mother-child Perinatal HIVTransmission
(University of NairobiDepartment of Medical Microbiology, 2013-04)Transplacental passage is a well-known phenomenon in HIV infection and immune responses at the maternal-fetal interface play a critical role in perinatal mother-to-child HIV transmission (MCHT). The high expression of HLA-G ... -
Immunogenicity Of Sequences Around Hiv-1 Protease Cleavage Sites: Potential Targets And Population Coverage Analysis For A Hiv Vaccine Targeting Protease Cleavage Sites.
(University of NairobiDepartment of Medical Microbiology, 2013-06)Developing an effective preventative vaccine against HIV-1 has proved to be a great challenge. The classical and proven vaccine approach has failed so far or produced a modest effect, new approaches are needed. In this ... -
Safety and immunogenicity of the malaria vaccine candidate MSP3 long synthetic peptide in 12-24 months-old Burkinabe children.
(College of Health Sciences,, 2009-10)BACKGROUND: A Phase Ia trial in European volunteers of the candidate vaccine merozoite surface protein 3 (MSP3), a Plasmodium falciparum blood stage membrane, showed that it induces biologically active antibodies able to ... -
Acting Locally: Innate Mucosal Immunity In Resistance To Hiv-1 Infection In Kenyan Commercial Sex Workers.
(University of NairobiDepartment of Medical Microbiology, 2013-06)Cohort studies of female commercial sex workers (CSWs) in Kenya were among the first to identify highly HIV-1-exposed seronegative (HESN) individuals. As natural resistance is usually mediated by innate immune mechanisms, ... -
Anticancer agents against malaria: time to revisit?
(University of Nairobi,College of Health Sciences,, 2010-03)The emergence of artemisinin resistance could adversely impact the current strategy for malaria treatment; thus, new drugs are urgently needed. A possible approach to developing new antimalarials is to find new uses for ... -
Engaging diverse communities participating in clinical trials: case examples from across Africa.
(University of Nairobi,College of Health Sciences,, 2010)BACKGROUND :In the advent of increasing international collaborative research involving participants drawn from populations with diverse cultural backgrounds, community engagement becomes very critical for the smooth ...
